Impaired vascular remodeling after endothelial progenitor cell transplantation in MMP9-deficient mice suffering cortical cerebral ischemia

被引：52

作者：

Morancho, Anna ^{[1
]}

Ma, Feifei ^{[1
]}

Barcelo, Veronica ^{[1
]}

Giralt, Dolors ^{[1
]}

Montaner, Joan ^{[1
]}

Rosell, Anna ^{[1
]}

机构：

[1] Univ Autonoma Barcelona, Vall dHebron Res Inst, Neurovasc Res Lab, E-08193 Barcelona, Spain

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2015年 / 35卷 / 10期

关键词：

angiogenesis; endothelial progenitor cell; matrix metalloproteinase-9; neurorepair; stroke; BLOOD-BRAIN-BARRIER; MATRIX METALLOPROTEINASES; MATRIX-METALLOPROTEINASE-9; STROKE;

D O I：

10.1038/jcbfm.2015.180

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Endothelial progenitor cells (EPCs) are being investigated for advanced therapies, and matrix metalloproteinase 9 (MMP9) has an important role in stroke recovery. Our aim was to determine whether tissue MMP9 influences the EPC-induced angiogenesis after ischemia. Wild-type (WT) and MMP9-deficient mice (MMP9/KO) were subjected to cerebral ischemia and treated with vehicle or outgrowth EPCs. After 3 weeks, we observed an increase in the peri-infarct vessel density in WT animals but not in MMP9/KO mice; no differences were found in the vehicle-treated groups. Our data suggest that tissue MMP9 has a crucial role in EPC-induced vascular remodeling after stroke.

引用

页码：1547 / 1551

页数：5

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