Gender differences in cholinergic and dopaminergic deficits in Parkinson disease

被引：24

作者：

Kotagal, Vikas ^{[1
]}

Albin, Roger L. ^{[1
,2
,3
]}

Mueller, Martijn L. T. M. ^{[4
]}

Koeppe, Robert A. ^{[4
]}

Frey, Kirk A. ^{[1
,4
]}

Bohnen, Nicolaas I. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Michigan, Dept Neurol, Ann Arbor, MI 48105 USA

[2] VAAAHS, Neurol Serv, Ann Arbor, MI USA

[3] VAAAHS, GRECC, Ann Arbor, MI USA

[4] Univ Michigan, Dept Radiol, Div Nucl Med, Ann Arbor, MI 48105 USA

来源：

JOURNAL OF NEURAL TRANSMISSION | 2013年 / 120卷 / 10期

关键词：

Gender; Women; Acetylcholine; Dopamine; Parkinson disease; BINDING; DENERVATION;

D O I：

10.1007/s00702-013-1013-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

As Parkinson disease (PD) may affect men and women differentially, we investigated gender differences in regional projection system integrity in 148 PD subjects (36 women, 112 men) using monoaminergic [C-11]dihydrotetrabenazine and acetylcholinesterase [C-11]PMP positron emission tomography. After controlling for age, disease duration, and Hoehn and Yahr score, men showed 5.9 % greater caudate dopaminergic denervation (p = 0.0018) and 5.8 % greater neocortical cholinergic denervation (p = 0.0097). No significant gender differences were seen in putaminal dopaminergic or thalamic cholinergic denervation.

引用

页码：1421 / 1424

页数：4

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