Clinical trials of arsenic trioxide in hematologic and slid tumors: Overview of the national cancer institute cooperative research and development studies

被引：175

作者：

Murgo, AJ ^{[1
]}

机构：

[1] NCI, Invest Drug Branch, Canc Therapy Evaluat Program, NIH, Rockville, MD 20852 USA

来源：

ONCOLOGIST | 2001年 / 6卷

关键词：

arsenic trioxide; Nnational Cancer Institute; hematologic malignancy; solid tumor;

D O I：

10.1634/theoncologist.6-suppl_2-22

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Arsenic trioxide inhibits growth and promotes apoptosis in many different cancer cell lines. The National Cancer Institute is working cooperatively with research centers across the U.S. to evaluate its clinical activity in hematologic malignancies, such as acute promyelocytic leukemia, acute myeloid leukemia, acute lymphocytic leukemia, chronic myelogenous leukemia, non-Hodgkin's lymphoma, Hodgkin's disease, chronic lymphocytic leukemia, myelodysplastic syndrome, and multiple myeloma. It is also supporting research in solid tumors, such as advanced hormone-refractory prostate cancer and renal cell cancer and in cervical cancer and refractory transitional cell carcinoma of the bladder. The safety and pharmacokinetics of arsenic trioxide are also being evaluated in pediatric patients with refractory leukemia and lymphoma. The results of these ongoing studies should provide important insights into the clinical utility of arsenic trioxide in these diseases.

引用

页码：22 / 28

页数：7

共 28 条

[1] Arsenic trioxide and interferon-α synergize to induce cell cycle arrest and apoptosis in human T-cell lymphotropic virus type I-transformed cells [J].

Bazarbachi, A ;

El-Sabban, ME ;

Nasr, R ;

Quignon, F ;

Awaraji, C ;

Kersual, J ;

Dianoux, L ;

Zermati, Y ;

Haidar, JH ;

Hermine, O ;

de Thé, H .

BLOOD, 1999, 93 (01) :278-283

[2]

Bazarbachi A, 1999, BLOOD, V94, p280A

[3]

CALLEJA EM, 1998, J CLIN ONCOL, V17, pA218

[4]

Chen GQ, 1998, BLOOD, V92, p638A

[5]

Chen GQ, 1997, BLOOD, V89, P3345

[6] Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system [J].

Dai, J ;

Weinberg, RS ;

Waxman, S ;

Jing, YK .

BLOOD, 1999, 93 (01) :268-277

[7]

El-Sabban ME, 2000, BLOOD, V96, P2849

[8] Arsenic trioxide induces apoptosis of myeloid leukemia cells by activation of caspases [J].

Huang, XJ ;

Wiernik, PH ;

Klein, RS ;

Gallagher, RE .

MEDICAL ONCOLOGY, 1999, 16 (01) :58-64

[9] Arsenic trioxide inhibits growth of human T-cell leukaemia virus type I infected T-cell lines more effectively than retinoic acids [J].

Ishitsuka, K ;

Hanada, S ;

Suzuki, S ;

Utsunomiya, A ;

Chyuman, Y ;

Takeuchi, S ;

Takeshita, T ;

Shimotakahara, S ;

Uozumi, I ;

Makino, T ;

Arima, T .

BRITISH JOURNAL OF HAEMATOLOGY, 1998, 103 (03) :721-728

[10]

Jing Y, 1999, BLOOD, V94, p505A

← 1 2 3 →