HLA-Ig-based artificial antigen-presenting cells: setting the terms of engagement

被引：22

作者：

Oelke, M ^{[1
]}

Schneck, JP ^{[1
]}

机构：

[1] Johns Hopkins Sch Med, Dept Pathol & Med, Baltimore, MD 21205 USA

来源：

CLINICAL IMMUNOLOGY | 2004年 / 110卷 / 03期

关键词：

class IHLA; CD8(+) CTL; infectious diseases; tumors; HLA-Ig dimer; adoptive immunotherapy;

D O I：

10.1016/j.clim.2003.11.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent advances in molecular medicine have shown that soluble MHC-multimers can be valuable tools for both the stimulation of as well as the analysis of antigen-specific T cells in vitro. In this review, we describe the use of dimeric major histocompatibility complexes, HLA-Ig, to visualize antigen-specific T cells as well as their potential to stimulate immune responses as part of an artificial antigen-presenting cell (aAPC). The use of HLA-Ig-based aAPC represents an exciting new approach to generate antigen-specific CTL for adoptive immunotherapy that helps to overcome many of the obstacles associated with limitations in current approaches to adoptive immunotherapy. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：243 / 251

页数：9

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