Antibiotics and Clostridium difficile

被引:67
作者
Freeman, J
Wilcox, MH [1 ]
机构
[1] Univ Leeds, Dept Microbiol, Leeds LS2 9JT, W Yorkshire, England
[2] Gen Infirm, Leeds LS2 9JT, W Yorkshire, England
关键词
Clostridium difficile infection pseudomembranous colitis; antibiotic-associated colitis; toxin production; adhesion;
D O I
10.1016/S1286-4579(99)80054-9
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Clostridium difficile is now established as a major nosocomial pathogen. C. difficile infection is seen almost exclusively as a complication of antibiotic therapy, and is particularly associated with clindamycin and third-generation cephalosporins. Depletion of the indigenous gut microflora by antibiotic therapy has long been established as a major factor in the disease. However, the direct influence of antimicrobials upon virulence mechanisms such as toxin production and adhesion in the bowel, and the exact mechanisms by which the organism causes disease remain to be elucidated. (C) Elsevier, Paris.
引用
收藏
页码:377 / 384
页数:8
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