Uric acid concentration as a risk marker for blood pressure progression and incident hypertension: A Chinese cohort study

被引：82

作者：

Yang, Tsan ^{[2
]}

Chu, Chi-Hong ^{[3
]}

Bai, Chyi-Huey ^{[4
]}

You, San-Lin ^{[5
,6
]}

Chou, Yu-Ching ^{[6
]}

Hwang, Lee-Ching ^{[7
]}

Chien, Kuo-Liong ^{[8
]}

Su, Ta-Chen ^{[9
]}

Tseng, Chin-Hsiao ^{[9
]}

Sun, Chien-An ^{[1
]}

机构：

[1] Fu Jen Catholic Univ, Coll Med, Dept Publ Hlth, New Taipei City 24205, Taiwan

[2] Meiho Univ, Dept Hlth Business Adm, Pingtung, Taiwan

[3] Natl Def Med Ctr, Dept Surg, Triserv Gen Hosp, Taipei, Taiwan

[4] Taipei Med Univ, Sch Publ Hlth, Coll Publ Hlth & Nutr, Taipei, Taiwan

[5] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

[6] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan

[7] Mackay Med Coll, New Taipei City, Taiwan

[8] Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei 10764, Taiwan

[9] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2012年 / 61卷 / 12期

关键词：

Abdominal obesity; Longitudinal study; Serum uric acid; METABOLIC SYNDROME; SERUM CREATININE; HEALTH SURVEY; TAIWAN; PREVALENCE; HYPERURICEMIA; CHOLESTEROL; AWARENESS; OBESITY;

D O I：

10.1016/j.metabol.2012.05.006

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Objective. Little is known about serum uric acid (SUA) role for hypertension in the Asian countries with low cardiovascular events. We aimed to explore the relationship in a comprehensive Chinese cohort. Methods. Participants in the Taiwanese Survey on Prevalences of Hypertension, Hyperglycemia, and Hyperlipidemia (TwSHHH) who were free of hypertension at baseline recruitment in 2002 (n=3257) were evaluated for the longitudinal association between baseline SUA and blood pressure progression (BPP) and incident hypertension. Results. During a mean follow-up of 5.41 years, 1119 persons (34.3%) had experienced progression to a higher blood pressure stage and 496 persons (15.2%) had developed hypertension. In multivariate analyses, the adjusted hazard ratios (HRs) [95% confidence intervals (Cls)] comparing the highest and lowest SUA quartiles were 1.78 (1.11-2.02, P for trend .004) for BPP and 1.68 (1.23-2.04, P for trend .028) for incident hypertension. The positively graded relationships between SUA concentration and blood pressure outcomes were observed in both males and females. More interestingly, a statistically significant trend for increasing risk of BPP and incident hypertension across SUA quartiles was most pronounced in participants with abdominal obesity. Conclusion. We concluded that SUA level was an independent predictor of blood pressure progression and incident hypertension in a Chinese population. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：1747 / 1755

页数：9

共 41 条

[1]

Black HR, 1997, ARCH INTERN MED, V157, P2413

[2]

Chang HY, 2001, J RHEUMATOL, V28, P1640

[3]

Serum Uric Acid Level as an Independent Risk Factor for All-Cause, Cardiovascular, and Ischemic Stroke Mortality: A Chinese Cohort Study [J].