Genetic maternal effects on human life span through the inheritance of mitochondrial DNA

被引：35

作者：

Korpelainen, H ^{[1
]}

机构：

[1] Univ Helsinki, Dept Biosci, Div Genet, FIN-00014 Helsinki, Finland

来源：

HUMAN HEREDITY | 1999年 / 49卷 / 04期

关键词：

mitochondria; mtDNA; maternal effects; human life span;

D O I：

10.1159/000022871

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Ageing consists of an accumulation of changes with time both at the molecular and cellular levels, accompanying an increased susceptibility to diseases and death, If maternally inherited mitochondrial genes are involved in defining the nature and timing of ageing, and if there are genetic differences in their susceptibility to damage, a maternal contribution could be found in the inheritance of life span, The present study explores the inheritance pattern of longevity and discovers a significant genetic maternal component in human life span.

引用

页码：183 / 185

页数：3

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