Circadian variation of granulocyte colony stimulating factor levels in man

被引：38

作者：

Jilma, B

Hergovich, N

Stohlawetz, P

Eichler, HG

Bauer, P

Wagner, OF

机构：

[1] Univ Hosp Vienna, Sch Med, Dept Clin Pharmacol, Adhes Res Grp Elaborating Therapeut,TARGET, A-1090 Vienna, Austria

[2] Univ Hosp Vienna, Dept Transfus Med, A-1090 Vienna, Austria

[3] Univ Hosp Vienna, Dept Med Stat, A-1090 Vienna, Austria

[4] Univ Hosp Vienna, Med & Chem Lab Diagnost, A-1090 Vienna, Austria

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1999年 / 106卷 / 02期

关键词：

circadian; diurnal; G-CSF; cortisol; plasma;

D O I：

10.1046/j.1365-2141.1999.01543.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glucocorticoids dose-dependently increase plasma levels of granulocyte colony stimulating factor (G-CSF). Based on the marked circadian rhythm of cortisol levels, we hypothesized that plasma levels of G-CSF may also show a diurnal rhythm. A prospective study was conducted in 12 healthy young volunteers. Blood samples were obtained every 2h over 24h. G-CSF levels averaged 18.0 ng/l (CI 1.31-22.9) at 8.00 am. increased continuously and reached peak values at 10.00 p.m. Individual harmonic regression analysis showed a clear circadian rhythm. The individual differences between nadir and peak levels averaged 54% (CI 43-65%). This pronounced diurnal rhythm of G-CSF levels may hell, understand the circadian changes in circulating stem cells, bone marrow DNA synthesis, or hone marrow toxicity induced by some chemotherapeutic agents.

引用

页码：368 / 370

页数：3

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