Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants

被引：58

作者：

Mohlke, Karen L. ^{[1
]}

Boehnke, Michael ^{[2
]}

Abecasis, Goncalo R. ^{[2
]}

机构：

[1] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA

[2] Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA

来源：

HUMAN MOLECULAR GENETICS | 2008年 / 17卷

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1093/hmg/ddn275

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genome-wide association studies are providing new insights into the genetic basis of metabolic and cardiovascular traits. In the past 3 years, common variants in similar to 50 loci have been strongly associated with metabolic and cardiovascular traits. Several of these loci have implicated genes without a previously known connection with metabolism. Further studies will be required to characterize the full impact of these loci on metabolism. Many of the identified loci include multiple independent variants that influence the same metabolic or cardiovascular trait and a few loci harbor independent variants that each influence distinct traits. The total proportion of trait heritability explained by variants identified so far is still modest (typically <10%). Future studies will build on these successes by identifying additional common and rare variants and by determining the functional impact of the underlying alleles and genes.

引用

页码：R102 / R108

页数：7

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