Immunoreceptor tyrosine-based inhibition motif-bearing receptors regulate the immunoreceptor tyrosine-based activation motif-induced activation of immune competent cells

被引：58

作者：

Gergely, J ^{[1
]}

Pecht, I

Sármay, G

机构：

[1] Weizmann Inst Sci, IL-71600 Rehovot, Israel

[2] Eotvos Lorand Univ, Dept Immunol, Hungarian Acad Sci, Res Grp, H-2131 God, Hungary

来源：

IMMUNOLOGY LETTERS | 1999年 / 68卷 / 01期

关键词：

ITAM; ITIM; immune competent cells;

D O I：

10.1016/S0165-2478(99)00024-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

ITIM-bearing receptors, a family which only recently has been recognized, play a key role in the regulation of the ITAM-induced activation of immune competent cells. The mechanism of ITM-mediated regulation in various cells was recently clarified. The present review focuses on ITIM bearing membrane proteins that negatively regulate the activation of cells when co-crosslinked with ITAM containing receptors, illustrates the inhibitory processes by the negative regulation of B-, NK-, T-cells and mast cells and summarizes current views on the mechanism of ITIM-mediated inhibition. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：3 / 15

页数：13

共 152 条

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