Synthesis of functionalized pyrrolidin-2-ones and (S)-Vigabatrin from pyrrole

被引：70

作者：

Gheorghe, A ^{[1
]}

Schulte, M ^{[1
]}

Reiser, O ^{[1
]}

机构：

[1] Univ Regensburg, Inst Organ Chem, D-93053 Regensburg, Germany

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 05期

关键词：

D O I：

10.1021/jo0524472

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from pyrrole, the novel 3,4-didehydropyrohomoglutamate 8 or (ent)-8 can be efficiently synthesized in up to 91% ee, which can be utilized as a versatile building block toward functionalized pyrrolidin-2-ones. Moreover, (ent)-8 can be readily converted to (S)-Vigabatrin, being an irreversible inhibitor for GABA-T, which is used as adjunctive therapy in patients that suffer from epilepsy.

引用

页码：2173 / 2176

页数：4

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