The role of circulating fibrocytes in inflammation and autoimmunity

被引：49

作者：

Galligan, Carole L.

Fish, Eleanor N. ^{[1
]}

机构：

[1] Univ Hlth Network, Toronto Gen Res Inst, Toronto, ON M5G 2M1, Canada

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2013年 / 93卷 / 01期

关键词：

Graves' disease; rheumatoid arthritis; scleroderma; cytokines; chemokines; PERIPHERAL-BLOOD FIBROCYTES; RHEUMATOID-ARTHRITIS; T-CELLS; SKIN FIBROSIS; UP-REGULATION; TGF-BETA; FIBROBLASTS; DISEASE; PATHOGENESIS; CHEMOKINES;

D O I：

10.1189/jlb.0712365

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Autoimmunity is a chronic process resulting in inflammation, tissue damage, and subsequent tissue remodeling. Circulating fibrocytes are bone marrow-derived cells with characteristics of hematopoietic and mesenchymal cells. These cells have been implicated in many inflammatory and fibrotic conditions as well as in wound healing. Fibrocytes can amplify the inflammatory/immune response through multiple mechanisms, including antigen presentation, cytokine and chemokine secretion, and production of MMPs. Increased numbers of circulating fibrocytes are observed in RA, systemic scleroderma, and Graves' disease. Here, we review the current literature and potential involvement of fibrocytes in inflammation and autoimmunity. J. Leukoc. Biol. 93: 45-50; 2013.

引用

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页码：45 / 50

页数：6

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