Umbilical cord blood transplantation and banking

被引：78

作者：

Brunstein, CG ^{[1
]}

Wagner, JE

机构：

[1] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Pediat, Blood & Marrow Transplant Program, Minneapolis, MN 55455 USA

来源：

ANNUAL REVIEW OF MEDICINE | 2006年 / 57卷

关键词：

UCB transplant; myeloablative UCB transplant; nonmyeloablative UCB transplant; double unit UCB grafts; UCB banking standards;

D O I：

10.1146/annurev.med.57.051804.123642

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Umbilical cord blood transplantation (UCBT) is an expanding practice for both pediatric and adult patients. Rapid availability, low risk of infectious disease transmission, lower risk of graft-versus-host disease, and lack of risk for the donor makes UCB an attractive alternative source of hematopoietic stem cells for transplantation. We review the state of the art of pediatric and adult UCBT and important aspects of UCB banking. Current strategies to improve clinical results and expand access to UCBT to a larger number of adult patients are discussed. New approaches to enhance hematopoietic recovery by the use of accessory cells or direct intra-bone marrow injection are also reviewed.

引用

页码：403 / 417

页数：15

共 78 条

[1]

*AM ASS BLOOD BANK, 2001, STAND UCB SERV

[2] Autografting followed by a reduced-intensity conditioning unrelated donor cord blood transplantation for a patient with refractory multiple myeloma: successful engraftment with minimal toxicity [J].