Synthesis, structural characterization and antioxidative properties of aminopyrazine and imidazolopyrazine derivatives

被引：27

作者：

Devillers, I

de Wergifosse, B

Bruneau, MP

Tinant, B

Declercq, JP

Touillaux, R

Rees, JF

Marchand-Brynaert, J

机构：

[1] Univ Catholique Louvain, Lab Chim Organ Synth, B-1348 Louvain, Belgium

[2] Univ Catholique Louvain, Physiol Anim Lab, B-1348 Louvain, Belgium

[3] Univ Catholique Louvain, Chim Phys & Cristallog Lab, B-1348 Louvain, Belgium

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 | 1999年 / 07期

关键词：

D O I：

10.1039/a900289h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of 2-aminopyrazine 1 with the glyoxal derivatives 2a-c gave the bicyclic imidazolopyrazinones 3a,b and the monocyclic N-substituted aminopyrazines 4b and 5c. Compounds 3 feature unique crystallographic characteristics. Their reactivity towards superoxide anion is about five times the reactivity of Trolox(R), while the monocyclic pyrazines are inactive.

引用

页码：1481 / 1487

页数：7

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