Intestinal stromal cells in mucosal immunity and homeostasis

被引：82

作者：

Owens, B. M. J. ^{[1
]}

Simmons, A. ^{[1
,2
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Med, Div Expt Med,Translat Gastroenterol Unit, Oxford OX3 9DU, England

[2] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, MRC Human Immunol Unit, Oxford OX3 9DU, England

来源：

MUCOSAL IMMUNOLOGY | 2013年 / 6卷 / 02期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

INFLAMMATORY-BOWEL-DISEASE; CROHNS-DISEASE; EPITHELIAL-CELLS; GENE-EXPRESSION; MAST-CELLS; SUBEPITHELIAL MYOFIBROBLASTS; MATRIX METALLOPROTEINASES; SYNOVIAL FIBROBLASTS; GROWTH-FACTOR; CROSS-TALK;

D O I：

10.1038/mi.2012.125

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A growing body of evidence suggests that non-hematopoietic stromal cells of the intestine have multiple roles in immune responses and inflammation at this mucosal site. Despite this, many still consider gut stromal cells as passive structural entities, with past research focused heavily on their roles in fibrosis, tumor progression, and wound healing, rather than their contributions to immune function. In this review, we discuss our current knowledge of stromal cells in intestinal immunity, highlighting the many immunological axes in which stromal cells have a functional role. We also consider emerging data that broaden the potential scope of their contribution to immunity in the gut and argue that these so-called "non-immune" cells are reclassified in light of their diverse contributions to intestinal innate immunity and the maintenance of mucosal homeostasis.

引用

页码：224 / 234

页数：11

共 127 条

[1] Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts [J].