Counter-effect of constrained dynamic loading on osteoporosis in ovariectomized mice

被引：21

作者：

Li, Hao ^{[1
]}

Li, Rui-Xin ^{[1
]}

Wan, Zong-Ming ^{[1
]}

Xu, Cheng ^{[1
]}

Li, Jian-Yu ^{[1
]}

Hao, Qing-Xin ^{[1
]}

Guo, Yong ^{[1
]}

Liu, Lu ^{[1
]}

Zhang, Xi-Zheng ^{[1
]}

机构：

[1] Acad Mil Med Sci, Inst Med Equipment, Tianjin 300161, Peoples R China

来源：

JOURNAL OF BIOMECHANICS | 2013年 / 46卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Osteoporosis; Dynamic loading; Counter-effect; Osteogenesis; Mechanical properties; MECHANICAL-PROPERTIES; BONE LOSS; RAT MODEL; MECHANOSTAT; PROPOSAL; MASS;

D O I：

10.1016/j.jbiomech.2013.02.016

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 [生物物理学];

摘要：

In recent years, dynamic mechanical loading has been shown to effectively enhance bone remodeling. The current study attempted to research the counter-effect of constrained dynamic loading on osteoporosis (OP) in ovariectomized (OVX) mice. Female Kunming (KM) mice were randomly divided into 2 groups: SHAM and OVX. The right ulnas of the OVX mice were subjected to a 4-week constrained dynamic loading protocol, and the mechanical properties, trabecular micromorphology parameters and biochemical indices of osteogenesis were evaluated. We detected higher levels of tissue alkaline phosphatase (AKP) and serum bone gamma-carboxyglutamic-acid-containing proteins (BGPs), better trabecular micromorphology parameters and ulnar mechanical properties in the loading group than in the nonloading group. In summary, constrained dynamic loading could prevent ovariectomy-induced osteoporosis by facilitating osteogenesis, improving trabecular microstructure and enhancing bone mechanical properties. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：1242 / 1247

页数：6

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