Sericins exhibit ROS-scavenging, anti-tyrosinase, anti-elastase, and in vitro immunomodulatory activities

被引：110

作者：

Chlapanidas, Theodora ^{[1
]}

Farago, Silvio ^{[2
]}

Lucconi, Giulia ^{[1
]}

Perteghella, Sara ^{[1
]}

Galuzzi, Marta ^{[1
,3
]}

Mantelli, Melissa ^{[4
]}

Avanzini, Maria Antonietta ^{[1
,4
]}

Tosca, Marta Cecilia ^{[1
,3
]}

Marazzi, Mario ^{[3
]}

Vigo, Daniele ^{[5
]}

Torre, Maria Luisa ^{[1
]}

Faustini, Massimo ^{[5
]}

机构：

[1] Univ Pavia, Dipartimento Sci Farmaco, I-27100 Pavia, Italy

[2] Innovhub, Stn Sperimentali Ind, Div Seta, Milan, Italy

[3] Azienda Osped Osped Niguarda Ca Granda, Milan, Italy

[4] Fdn IRCCS Policlin S Matteo, Lab Immunol & Trapianti, Pavia, Italy

[5] Univ Milan, Dipartimento Sci Vet & Sanita Pubbl, Milan, Italy

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2013年 / 58卷

关键词：

Sericin; ROS-scavenging activity; Anti-tyrosinase activity; Anti-elastase activity; Anti-proliferative activity; Anti-IFN gamma activity; SILK PROTEIN SERICIN; SKIN FIBROBLAST ELASTASE; BLOOD MONONUCLEAR-CELLS; BOMBYX-MORI; ARTIFICIAL DIET; OXIDATIVE STRESS; ISLET CULTURE; UP-REGULATION; ANTIOXIDANT; SILKWORMS;

D O I：

10.1016/j.ijbiomac.2013.03.054

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Some biological properties of Bombyx mori sericins from twenty strains were investigated, fourteen fed with artificial diet, two with fresh mulberry leaves and four with both diets. Sericin exhibited ROS-scavenging, anti-tyrosinase and anti-elastase properties, the strain significantly influenced these properties, while diet only influenced the anti-tyrosinase activity. Sericins were clustered into 5 groups and one sericin from each group was further studied: sericins showed anti-proliferative activity on in vitro stimulated peripheral blood mononuclear cells; some strains decreased in vitro secretion of IFN gamma, while no effects were observed on TNF alpha and IL10 release. Therefore, a mixture of sericins extracted from the most promising strains may be useful for dermatological and cosmetic use. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：47 / 56

页数：10

共 51 条

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