ANRIL: Molecular Mechanisms and Implications in Human Health

被引：229

作者：

Congrains, Ada ^{[1
]}

Kamide, Kei ^{[1
]}

Ohishi, Mitsuru ^{[1
]}

Rakugi, Hiromi ^{[1
]}

机构：

[1] Osaka Univ, Dept Geriatr Med & Nephrol, Grad Sch Med, Suita, Osaka 5650871, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 01期

关键词：

ANRIL; CDKN2BAS; polycomb proteins; 9p21; GENOME-WIDE ASSOCIATION; CORONARY-ARTERY-DISEASE; LONG NONCODING RNA; METHYLTHIOADENOSINE PHOSPHORYLASE MTAP; POLYCOMB TARGET GENES; INK4/ARF LOCUS; CELL SENESCENCE; DOWN-REGULATION; HUMAN CANCER; 9P21; LOCUS;

D O I：

10.3390/ijms14011278

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

ANRIL is a recently discovered long non-coding RNA encoded in the chromosome 9p21 region. This locus is a hotspot for disease-associated polymorphisms, and it has been consistently associated with cardiovascular disease, and more recently with several cancers, diabetes, glaucoma, endometriosis among other conditions. ANRIL has been shown to regulate its neighbor tumor suppressors CDKN2A/B by epigenetic mechanisms and thereby regulate cell proliferation and senescence. However, the clear role of ANRIL in the pathogenesis of these conditions is yet to be understood. Here, we review the recent findings on ANRIL molecular characterization and function, with a particular focus on its implications in human disease.

引用

页码：1278 / 1292

页数：15

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