Serological comparison of serum pepsinogen and antiparietal cell antibody levels between Japanese and German patients

被引:15
作者
Ito, M [1 ]
Haruma, K [1 ]
Kaya, S [1 ]
Kamada, T [1 ]
Kim, S [1 ]
Sasaki, A [1 ]
Sumii, M [1 ]
Tanaka, S [1 ]
Yoshihara, M [1 ]
Wagner, S [1 ]
Chayama, K [1 ]
机构
[1] Hiroshima Univ, Sch Med, Dept Internal Med 1, Hiroshima 734, Japan
关键词
anti-parietal cell antibody; atrophic gastritis; Helicobacter pylori; international comparison;
D O I
10.1097/00042737-200202000-00005
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background Atrophic gastritis is more common in Japan than in Germany. The expression of anti-parietal cell antibody has been implicated in the genesis of atrophic gastritis associated with Helicobacter pylori infection. Objective We investigated the difference in serum levels of pepsinogens and in anti-parietal cell antibody expression between Japanese and German patients. Methods We recruited 102 Japanese and 46 German patients with dyspepsia. Endoscopic examination detected no localized lesions in the upper gastrointestinal tract of any patients. Anti-parietal cell antibody was investigated by enzyme-linked immunosorbent assay with the purified porcine H+,K+-ATPase fraction and immunohistochemistry. H. pylori infection was diagnosed by the presence of anti-H. pylori antibody, by using the urease test and by histological examination. Serum levels of pepsinogen I and II and of gastrin were measured by a modified radioimmunoassay. Results Seventy-one Japanese (70%) and 17 Germans (37%) were positive for H. pylori. Serum levels of anti-parietal cell antibody were not significantly different between Japanese and Germans in both H. pylori negative and positive groups. The serum pepsinogen I/II ratio and gastrin levels were altered by H. pylori infection in both populations. Moreover, anti-parietal cell antibody levels were higher in H. pylori-positive patients with low pepsinogen levels than in those with high pepsinogen levels in both populations. Conclusions The levels of anti-parietal cell antibody do not differ statistically between Japanese and Germans. Anti-parietal cell antibody might play a role in the progression of atrophic gastritis in both Japanese and German patients. Eur J Gastroenterol Hepatol 14:123-127 (C) 2002 Lippincott Williams Wilkins.
引用
收藏
页码:123 / 127
页数:5
相关论文
共 32 条
[1]  
ASAKA M, 1994, CANCER, V73, P2691, DOI 10.1002/1097-0142(19940601)73:11<2691::AID-CNCR2820731107>3.0.CO
[2]  
2-2
[3]   RELATIONSHIP OF HELICOBACTER-PYLORI TO SERUM PEPSINOGENS IN AN ASYMPTOMATIC JAPANESE POPULATION [J].
ASAKA, M ;
KIMURA, T ;
KUDO, M ;
TAKEDA, H ;
MITANI, S ;
MIYAZAKI, T ;
MIKI, K ;
GRAHAM, DY .
GASTROENTEROLOGY, 1992, 102 (03) :760-766
[4]   CONTRIBUTION OF HLA-DQA GENE TO HOSTS RESPONSE AGAINST HELICOBACTER-PYLORI [J].
AZUMA, T ;
KONISHI, J ;
TANAKA, Y ;
HIRAI, M ;
ITO, S ;
KATO, T ;
KOHLI, Y .
LANCET, 1994, 343 (8896) :542-543
[5]   SERUM PEPSINOGEN-I AND PEPSINOGEN-II CONCENTRATIONS AND IGG ANTIBODY TO HELICOBACTER-PYLORI IN DYSPEPTIC PATIENTS [J].
BIASCO, G ;
PAGANELLI, GM ;
VAIRA, D ;
HOLTON, J ;
DIFEBO, G ;
BRILLANTI, S ;
MIGLIOLI, M ;
BARBARA, L ;
SAMLOFF, IM .
JOURNAL OF CLINICAL PATHOLOGY, 1993, 46 (09) :826-828
[6]  
BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[7]   The gastric H+,K+-ATPase is a major autoantigen in chronic Helicobacter pylori gastritis with body mucosa atrophy [J].
Claeys, D ;
Faller, G ;
Appelmelk, BJ ;
Negrini, R ;
Kirchner, T .
GASTROENTEROLOGY, 1998, 115 (02) :340-347
[8]  
CORREA P, 1995, AM J SURG PATHOL, V19, pS37
[9]   Interleukin-1 polymorphisms associated with increased risk of gastric cancer [J].
El-Omar, EM ;
Carrington, M ;
Chow, WH ;
McColl, KEL ;
Bream, JH ;
Young, HA ;
Herrera, J ;
Lissowska, J ;
Yuan, CC ;
Rothman, N ;
Lanyon, G ;
Martin, M ;
Fraumeni, JF ;
Rabkin, CS .
NATURE, 2000, 404 (6776) :398-402
[10]  
Faller G, 1998, SCAND J GASTROENTERO, V33, P276, DOI 10.1080/00365529850170865