Endocytic Receptors in the Renal Proximal Tubule

被引：237

作者：

Christensen, Erik I. ^{[1
]}

Birn, Henrik ^{[1
]}

Storm, Tina ^{[1
]}

Weyer, Kathrin ^{[1
]}

Nielsen, Rikke ^{[1
]}

机构：

[1] Aarhus Univ, Dept Biomed, Fac Hlth Sci, Aarhus, Denmark

来源：

PHYSIOLOGY | 2012年 / 27卷 / 04期

关键词：

DENSITY-LIPOPROTEIN RECEPTOR; FACTOR-VITAMIN B-12; MEGALIN-MEDIATED ENDOCYTOSIS; IMERSLUND-GRASBECK-SYNDROME; REGULATED INTRAMEMBRANE PROTEOLYSIS; HEYMANN NEPHRITIS; BRUSH-BORDER; TERATOGENIC ANTIBODIES; ALBUMIN REABSORPTION; ADAPTER PROTEIN;

D O I：

10.1152/physiol.00022.2012

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

Protein reabsorption is a predominant feature of the renal proximal tubule. Animal studies show that the ability to rescue plasma proteins relies on the endocytic receptors megalin and cubilin. Recently, studies of patients with syndromes caused by dysfunctional receptors have supported the importance of these for protein clearance of human ultrafiltrate. This review focuses on the molecular biology and physiology of the receptors and their involvement in renal pathological conditions.

引用

收藏

页码：223 / 236

页数：14

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