Rapidly light-activated surgical protein glue inspired by mussel adhesion and insect structural crosslinking

被引：158

作者：

Jeon, Eun Young ^{[1
]}

Hwang, Byeong Hee ^{[1
,2
]}

Yang, Yun Jung ^{[1
]}

Kim, Bum Jin ^{[1
]}

Choi, Bong-Hyuk ^{[1
]}

Jung, Gyu Yong ^{[3
]}

Cha, Hyung Joon ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol, Dept Chem Engn, Pohang 790784, South Korea

[2] Incheon Natl Univ, Div Bioengn, Inchon 406772, South Korea

[3] Dongguk Univ, Coll Med, Dept Plast Surg, Gyeongiu 780714, South Korea

来源：

BIOMATERIALS | 2015年 / 67卷

关键词：

Mussel adhesive protein; Protein adhesive; Tissue adhesive; Light-activated hydrogel; Dityrosine crosslinks; IN-VIVO; DITYROSINE; DOPA; HYDROGELS; RESILIN; TISSUES;

D O I：

10.1016/j.biomaterials.2015.07.014

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Currently approved surgical tissue glues do not satisfy the requirements for ideal bioadhesives due to limited adhesion in wet conditions and severe cytotoxicity. Herein, we report a new light-activated, mussel protein-based bioadhesive (LAMBA) inspired by mussel adhesion and insect dityrosine cross-linking chemistry. LAMBA exhibited substantially stronger bulk wet tissue adhesion than commercially available fibrin glue and good biocompatibility in both in vitro and in vivo studies. Besides, the easily tunable, light-activated crosslinking enabled an effective on-demand wound closure and facilitated wound healing. Based on these outstanding properties, LAMBA holds great potential as an ideal surgical tissue glue for diverse medical applications, including sutureless wound closures of skin and internal organs. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：11 / 19

页数：9

共 34 条

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