Pediatric anti-NMDA receptor encephalitis is seasonal

被引：34

作者：

Adang, Laura A. ^{[1
,2
]}

Lynch, David R. ^{[1
,2
,3
,4
,5
]}

Panzer, Jessica A. ^{[1
,2
]}

机构：

[1] Univ Penn, Dept Pediat, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

[3] Univ Penn, Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA

[4] Univ Penn, Childrens Hosp Philadelphia, Dept Child Psychiat, Philadelphia, PA 19104 USA

[5] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2014年 / 1卷 / 11期

关键词：

D O I：

10.1002/acn3.100

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

In the majority of pediatric anti-N-methyl-D-aspartate receptor encephalitis (NMDARe) cases, the underlying cause of antibody production and subsequent disease remains unknown. We aimed to characterize this poorly understood population, investigating epidemiological factors potentially related to disease etiology, particularly season of onset. In this retrospective case review study, we analyzed data from the 29 pediatric subjects with anti-NMDAR antibodies and found that symptoms were first reported in the warm months of April-September in 78% of non-tumor-related NMDARe (NT-NMDARe) cases. These findings support further investigation into a possible seasonal trigger of NT-NMDARe.

引用

页码：921 / 925

页数：5

共 15 条

[1]

[Anonymous], DAT TOOLS 1981 2010

[2]

Autoimmune Encephalitis in Children [J].

Armangue, Thais ;

Petit-Pedrol, Mar ;

Dalmau, Josep .

JOURNAL OF CHILD NEUROLOGY, 2012, 27 (11) :1460-1469

[3]

Epstein-Barr virus infection in children with renal transplantation: 17 years experience at a single center [J].

Comak, Elif ;

Akman, Sema ;

Ongut, Gozde ;

Colak, Dilek ;

Koyun, Mustafa ;

Dogan, Cagla Serpil ;

Mutlu, Derya ;

Saglik, Imran ;

Gokceoglu, Arife Uslu ;

Dinckan, Ayhan .

RENAL FAILURE, 2014, 36 (05) :760-766

[4]

Increased risk of narcolepsy in children and adults after pandemic H1N1 vaccination in France [J].

Dauvilliers, Yves ;

Arnulf, Isabelle ;

Lecendreux, Michel ;

Charley, Christelle Monaca ;

Franco, Patricia ;

Drouot, Xavier ;

d'Ortho, Marie-Pia ;

Launois, Sandrine ;

Lignot, Severine ;

Bourgin, Patrice ;

Nogues, Beatrice ;

Rey, Marc ;

Bayard, Sophie ;

Scholz, Sabine ;

Lavault, Sophie ;

Tubert-Bitter, Pascale ;

Saussier, Cristel ;

Pariente, Antoine .

BRAIN, 2013, 136 :2486-2496

[5]

Anti-N-Methyl-D-Aspartate Receptor (NMDAR) Encephalitis in Children and Adolescents [J].

Florance, Nicole R. ;

Davis, Rebecca L. ;

Lam, Christopher ;

Szperka, Christina ;

Zhou, Lei ;

Ahmad, Saba ;

Campen, Cynthia J. ;

Moss, Heather ;

Peter, Nadja ;

Gleichman, Amy J. ;

Glaser, Carol A. ;

Lynch, David R. ;

Rosenfeld, Myrna R. ;

Dalmau, Josep .

ANNALS OF NEUROLOGY, 2009, 66 (01) :11-18

[6]

Anti-NMDA Receptor Encephalitis Antibody Binding Is Dependent on Amino Acid Identity of a Small Region within the GluN1 Amino Terminal Domain [J].

Gleichman, Amy J. ;

Spruce, Lynn A. ;

Dalmau, Josep ;

Seeholzer, Steven H. ;

Lynch, David R. .

JOURNAL OF NEUROSCIENCE, 2012, 32 (32) :11082-11094

[7]

N-Methyl-D-Aspartate Receptor Antibodies in Post-Herpes Simplex Virus Encephalitis Neurological Relapse [J].

Hacohen, Yael ;

Deiva, Kumaran ;

Pettingill, Phillipa ;

Waters, Patrick ;

Siddiqui, Ata ;

Chretien, Pascale ;

Menson, Esse ;

Lin, Jean-Pierre ;

Tardieu, Marc ;

Vincent, Angela ;

Lim, Ming J. .

MOVEMENT DISORDERS, 2014, 29 (01) :90-96

[8]

Update on Pediatric Opsoclonus Myoclonus Syndrome [J].

Hero, Barbara ;

Schleiermacher, Gudrun .

NEUROPEDIATRICS, 2013, 44 (06) :324-329

[9]

Seasonal changes in activities of human neutrophils in vitro [J].

Klink, Magdalena ;

Bednarska, Katarzyna ;

Blus, Edyta ;

Kielbik, Michal ;

Sulowska, Zofia .

INFLAMMATION RESEARCH, 2012, 61 (01) :11-16

[10]

Lezcano A, 2008, ARCH ARGENT PEDIATR, V106, P6

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