Two successful pregnancies after conservative treatment of endometrial cancer and assisted reproduction

Objective: To report successful pregnancies after conservative management of FIGO grade I adenocarcinoma of the endometrium. Design: Retrospective chart review Setting: University-based assisted reproduction and oncology units. Patient(s): One patient who had two separate pregnancies. Intervention(s): High-dose progestin (megestrol acetate) therapy for adenocarcinoma, followed by assisted reproduction with donor oocyte. Main Outcome Measure(s): Histologic evaluation of endometrium after megestrol acetate and at completion of childbearing, and successful pregnancies and deliveries. Result(s): The patient had complete resolution of adenocarcinoma with progestin therapy and successful delivery of two pregnancies after assisted reproduction. Conclusion(s): Conservative management of International Federation of Gynecology and Obstetrics grade I adenocarcinoma of the endometrium allows preservation of childbearing. (Fertil Steril(R) 2002;77:188-9. (C) 2002 by American Society for Reproductive Medicine).