The role of ERK and JNK signaling in connective tissue growth factor induced extracellular matrix protein production and scar formation

被引：87

作者：

Hu, Xiaolong ^{[1
]}

Wang, Hongtao ^{[1
]}

Liu, Jiaqi ^{[1
]}

Fang, Xiaobing ^{[1
]}

Tao, Ke ^{[1
]}

Wang, Yaojun ^{[1
]}

Li, Na ^{[1
]}

Shi, Jihong ^{[1
]}

Wang, Yunchuan ^{[1
]}

Ji, Peng ^{[1
]}

Cai, Weixia ^{[1
]}

Bai, Xiaozhi ^{[1
]}

Zhu, Xiongxiang ^{[1
]}

Han, Juntao ^{[1
]}

Hu, Dahai ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp, Dept Burns & Cutaneous Surg, Xian 710032, Shaanxi, Peoples R China

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 2013年 / 305卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Hypertrophic scar; Extracellular signal-regulated kinase; c-Jun N-terminal kinase; Connective tissue growth factor; Scar formation; FACTOR-BETA; SKELETAL DEVELOPMENT; COLLAGEN EXPRESSION; KELOID FIBROBLASTS; FIBROSIS; PATHWAY; MAPK; CCN2; DIFFERENTIATION; HYPERTROPHY;

D O I：

10.1007/s00403-013-1334-9

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

CCN2 plays an important role in the pathogenesis of hypertrophic scars (HTSs). Although CCN2 is involved in many fibroproliferative events, the CCN2 induction signaling pathway in HTSs is yet to be elucidated. Here, we first investigated the effect of the mitogen-activated protein kinases (MAPKs) on CCN2-induced alpha-smooth muscle actin (alpha-SMA) and collagen I expression in human HTS fibroblasts (HTSFs). Then, we established HTSs in a rabbit ear model and determined the effect of MAPKs on the pathogenesis of HTSs. MAPK pathways were activated by CCN2 in HTSFs. Extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) inhibitors significantly inhibited CCN2-induced expression of alpha-SMA and collagen I in HTSFs. In the rabbit ear model of the HTS, JNK and ERK inhibitors significantly improved the architecture of the rabbit ear scar and reduced scar formation on the rabbit ear. Our results indicate that ERK and JNK mediate collagen I expression and scarring of the rabbit ear, and may be considered for specific drug therapy targets for HTSs.

引用

页码：433 / 445

页数：13

共 35 条

[1]

Skin scarring [J].