How Taxol® stabilises microtubule structure

被引：221

作者：

Amos, LA ^{[1
]}

Löwe, J ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

来源：

CHEMISTRY & BIOLOGY | 1999年 / 6卷 / 03期

关键词：

D O I：

10.1016/S1074-5521(99)89002-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The structure of tubulin shows paclitaxel (Taxol (R)) binding to a pocket in beta tubulin on the microtubule's inner surface, which counteracts the effects of GTP hydrolysis occurring on the other side of the monomer.

引用

页码：R65 / R69

页数：5

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