HIV infection:: pre-highly active antiretroviral therapy IL-7 plasma levels correlate with long-term CD4 cell count increase after treatment

被引：30

作者：

Beq, S ^{[1
]}

Rannou, MT

Fontanet, A

Delfraissy, JF

Thèze, J

Colle, JH

机构：

[1] Inst Pasteur, Unite Immunol Genet Cellulaire, Paris, France

[2] Hop Bicetre Assistance Publ, Med Serv, Hop Paris, Paris, France

[3] Inst Pasteur, Unite Epidemiol Malades Emergentes, Paris, France

来源：

AIDS | 2004年 / 18卷 / 03期

关键词：

D O I：

10.1097/00002030-200402200-00025

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Highly active antiretroviral therapy (HAART) in HIV patients generally increases the CD4 cell count, but the level of CD4 cell restoration remains very heterogeneous. IL-7 is the main cytokine controlling the size of the T-cell pool. We assessed the hypothesis that pre-HAART IL-7 plasma levels may affect CD4 cell restoration after treatment. A positive correlation was found in a cohort of 18 patients between pre-HAART IL-7 plasma levels and CD4 cell increases after 20 +/- 7.8 months of HAART.

引用

页码：563 / 565

页数：3

共 7 条

[1] Interleukin-7: from bench to clinic [J].

Fry, TJ ;

Mackall, CL .

BLOOD, 2002, 99 (11) :3892-3904

[2] A potential role for interleukin-7 in T-cell homeostasis [J].

Fry, TJ ;

Connick, E ;

Falloon, J ;

Lederman, MM ;

Liewehr, DJ ;

Spritzler, J ;

Steinberg, SM ;

Wood, LV ;

Yarchoan, R ;

Zuckerman, J ;

Landay, A ;

Mackall, CL .

BLOOD, 2001, 97 (10) :2983-2990

[3] CD4+ T-cell depletion in HIV infection:: Are we closer to understanding the cause? [J].

Grossman, Z ;

Meier-Schellersheim, M ;

Sousa, AE ;

Victorino, RMM ;

Paul, WE .

NATURE MEDICINE, 2002, 8 (04) :319-323

[4] T cell depletion in HIV-I infection:: how CD4+ T cells go out of stock [J].

Hazenberg, MD ;

Hamann, D ;

Schuitemaker, H ;

Miedema, F .

NATURE IMMUNOLOGY, 2000, 1 (04) :285-289

[5] Increased production of IL-7 accompanies HIV-l-mediated T-cell depletion: implications for T-cell homeostasis [J].

Napolitano, LA ;

Grant, RM ;

Deeks, SG ;

Schmidt, D ;

De Rosa, SC ;

Herzenberg, LA ;

Herndier, BG ;

Andersson, J ;

McCune, JM .

NATURE MEDICINE, 2001, 7 (01) :73-79

[6] AIDS pathogenesis: what have two decades of HIV research taught us? [J].

Rowland-Jones, SL .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (04) :343-348

[7] Endogenous IL-7 is associated with increased thymic volume in adult HIV-infected patients under highly active antiretroviral therapy [J].

Ruiz-Mateos, E ;

de la Rosa, R ;

Franco, JM ;

Martinez-Moya, M ;

Rubio, A ;

Soriano, N ;

Sanchez-Quijano, A ;

Lissen, E ;

Leal, M .

AIDS, 2003, 17 (07) :947-954

← 1 →