Kinase Inhibition - A New Approach to the Treatment of Rheumatoid Arthritis

被引：21

作者：

Fox, David A. ^{[1
]}

机构：

[1] Univ Michigan, Dept Internal Med, Div Rheumatol, Ann Arbor, MI 48109 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2012年 / 367卷 / 06期

关键词：

JAK INHIBITOR; TOFACITINIB; CP-690,550; PLACEBO; TRIAL;

D O I：

10.1056/NEJMe1206315

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

引用

页码：565 / 567

页数：3

共 15 条

[1]

Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor [J].

Changelian, PS ;

Flanagan, ME ;

Ball, DJ ;

Kent, CR ;

Magnuson, KS ;

Martin, WH ;

Rizzuti, BJ ;

Sawyer, PS ;

Perry, BD ;

Brissette, WH ;

McCurdy, SP ;

Kudlacz, EM ;

Conklyn, MJ ;

Elliott, EA ;

Koslov, ER ;

Fisher, MB ;

Strelevitz, TJ ;

Yoon, K ;

Whipple, DA ;

Sun, JM ;

Munchhof, MJ ;

Doty, JL ;

Casavant, JM ;

Blumenkopf, TA ;

Hines, M ;

Brown, MF ;

Lillie, BM ;

Subramanyam, C ;

Shang-Poa, C ;

Milici, AJ ;

Beckius, GE ;

Moyer, JD ;

Su, CY ;

Woodworth, TG ;

Gaweco, AS ;

Beals, CR ;

Littman, BH ;

Fisher, DA ;

Smith, JF ;

Zagouras, P ;

Magna, HA ;

Saltarelli, MJ ;

Johnson, KS ;

Nelms, LF ;

Des Etages, SG ;

Hayes, LS ;

Kawabata, TT ;

Finco-Kent, D ;

Baker, DL ;

Larson, M .

SCIENCE, 2003, 302 (5646) :875-878

[2]

Sensitivity and Resistance to Regulation by IL-4 during Th17 Maturation [J].

Cooney, Laura A. ;

Towery, Keara ;

Endres, Judith ;

Fox, David A. .

JOURNAL OF IMMUNOLOGY, 2011, 187 (09) :4440-4450

[3]

Placebo-Controlled Trial of Tofacitinib Monotherapy in Rheumatoid Arthritis [J].

Fleischmann, Roy ;

Kremer, Joel ;

Cush, John ;

Schulze-Koops, Hendrik ;

Connell, Carol A. ;

Bradley, John D. ;

Gruben, David ;

Wallenstein, Gene V. ;

Zwillich, Samuel H. ;

Kanik, Keith S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (06) :495-507

[4]

Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550) [J].

Ghoreschi, Kamran ;

Jesson, Michael I. ;

Li, Xiong ;

Lee, Jamie L. ;

Ghosh, Sarbani ;

Alsup, Jason W. ;

Warner, James D. ;

Tanaka, Masao ;

Steward-Tharp, Scott M. ;

Gadina, Massimo ;

Thomas, Craig J. ;

Minnerly, John C. ;

Storer, Chad E. ;

LaBranche, Timothy P. ;

Radi, Zaher A. ;

Dowty, Martin E. ;

Head, Richard D. ;

Meyer, Debra M. ;

Kishore, Nandini ;

O'Shea, John J. .

JOURNAL OF IMMUNOLOGY, 2011, 186 (07) :4234-4243

[5]

Kontzias Apostolos, 2012, F1000 Med Rep, V4, P5, DOI 10.3410/M4-5

[6]

The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo (vol 60, pg 1895, 2009) [J].

Kremer, Joel M. ;

Bloom, Bradley J. ;

Breedveld, Ferdinand C. ;

Coombs, John H. ;

Fletcher, Mark P. ;

Gruben, David ;

Krishnaswami, Sriram ;

Burgos-Vargas, Ruben ;

Wilkinson, Bethanie ;

Zerbini, Cristiano A. F. ;

Zwillich, Samuel H. .

ARTHRITIS AND RHEUMATISM, 2012, 64 (05) :1487-1487

[7]

The Safety and Efficacy of a JAK Inhibitor in Patients With Active Rheumatoid Arthritis Results of a Double-Blind, Placebo-Controlled Phase IIa Trial of Three Dosage Levels of CP-690,550 Versus Placebo [J].

Kremer, Joel M. ;

Bloom, Bradley J. ;

Breedveld, Ferdinand C. ;

Coombs, John H. ;

Fletcher, Mark P. ;

Gruben, David ;

Krishnaswami, Sriram ;

Burgos-Vargas, Ruben ;

Wilkinson, Bethanie ;

Zerbini, Cristiano A. F. ;

Zwillich, Samuel H. .

ARTHRITIS AND RHEUMATISM, 2009, 60 (07) :1895-1905

[8]

Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis [J].

Milici, Anthony J. ;

Kudlacz, Elizabeth M. ;

Audoly, Laurent ;

Zwillich, Samuel ;

Changelian, Paul .

ARTHRITIS RESEARCH & THERAPY, 2008, 10 (01)

[9]

Jak3 and the pathogenesis of severe combined immunodeficiency [J].

O'Shea, JJ ;

Husa, M ;

Li, D ;

Hofmann, SR ;

Watford, W ;

Roberts, JL ;

Buckley, RH ;

Changelian, P ;

Candotti, F .

MOLECULAR IMMUNOLOGY, 2004, 41 (6-7) :727-737

[10]

A new modality for immunosuppression: Targeting the JAK/STAT pathway [J].

O'Shea, JJ ;

Pesu, M ;

Borie, DC ;

Changelian, PS .

NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (07) :555-564

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