Mechanisms of Disease Progression in NASH: New Paradigms

被引：56

作者：

Bohinc, Brittany N. ^{[2
]}

Diehl, Anna Mae ^{[1
]}

机构：

[1] Duke Univ, Div Gastroenterol, Duke Liver Ctr, Durham, NC 27710 USA

[2] Duke Univ Hosp, Dept Diabet Endocrinol & Metab, Durham, NC 27710 USA

来源：

CLINICS IN LIVER DISEASE | 2012年 / 16卷 / 03期

关键词：

NASH; Nonalcoholic steatohepatitis; Hedgehog signaling pathway; Hepatocellular carcinoma; Cirrhosis; Hepatic fibrosis; FATTY LIVER-DISEASE; HEPATIC STELLATE CELLS; NF-KAPPA-B; HEDGEHOG PATHWAY ACTIVATION; KILLER T-CELLS; HUMAN NONALCOHOLIC STEATOHEPATITIS; HUMAN HEPATOCELLULAR-CARCINOMA; PRIMARY BILIARY-CIRRHOSIS; INVARIANT NKT CELLS; SONIC-HEDGEHOG;

D O I：

10.1016/j.cld.2012.05.002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

The incidence of nonalcoholic fatty liver disease is increasing at an astonishing rate in the US population. Although only a small proportion of these patients develop steatohepatitis (NASH), those who do have a greater likelihood of developing end-stage liver disease and complications. Research on liver fibrosis and NASH progression shows that hedgehog (Hh) is reactivated after liver injury to assist in liver repair and regeneration. When the process of tissue repair and regeneration is prolonged or when Hh ligand and related genes are aberrantly regulated and excessive, tissue repair goes awry and NASH progresses to cirrhosis and hepatocellular carcinoma.

引用

页码：549 / +

页数：18

共 137 条

[1]

Increased Fructose Consumption Is Associated with Fibrosis Severity in Patients with Nonalcoholic Fatty Liver Disease [J].

Abdelmalek, Manal F. ;

Suzuki, Ayako ;

Guy, Cynthia ;

Unalp-Arida, Aynur ;

Colvin, Ryan ;

Johnson, Richard J. ;

Diehl, Anna Mae .

HEPATOLOGY, 2010, 51 (06) :1961-1971

[2]

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease [J].

Acloque, Herve ;

Adams, Meghan S. ;

Fishwick, Katherine ;

Bronner-Fraser, Marianne ;

Angela Nieto, M. .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (06) :1438-1449

[3]

Other disease associations with non-alcoholic fatty liver disease (NAFLD) [J].

Allard, JP .

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2002, 16 (05) :783-795

[4]

Hypoxic stimulation of vascular endothelial growth factor expression in activated rat hepatic stellate cells [J].

Ankoma-Sey, V ;

Wang, Y ;

Dai, ZH .

HEPATOLOGY, 2000, 31 (01) :141-148

[5]

Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling [J].

Asai, Jun ;

Takenaka, Hideya ;

Kusano, Kengo F. ;

Ii, Masaaki ;

Luedemann, Corinne ;

Curry, Cynthia ;

Eaton, Elizabeth ;

Iwakura, Atsushi ;

Tsutsumi, Yoshiaki ;

Hamada, Hiromichi ;

Kishimoto, Saburo ;

Thorne, Tina ;

Kishore, Raj ;

Losordo, Douglas W. .

CIRCULATION, 2006, 113 (20) :2413-2424

[6]

Transitions between epithelial and mesenchymal states in development and disease [J].

Baum, Buzz ;

Settleman, Jeffrey ;

Quinlan, Margaret P. .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2008, 19 (03) :294-308

[7]

Tissue repair and stem cell renewal in carcinogenesis [J].

Beachy, PA ;

Karhadkar, SS ;

Berman, DM .

NATURE, 2004, 432 (7015) :324-331

[8]

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours [J].

Berman, DM ;

Karhadkar, SS ;

Maitra, A ;

de Oca, RM ;

Gerstenblith, MR ;

Briggs, K ;

Parker, AR ;

Shimada, Y ;

Eshleman, JR ;

Watkins, DN ;

Beachy, PA .

NATURE, 2003, 425 (6960) :846-851

[9]

Association between microsomal triglyceride transfer protein gene polymorphism and the biological features of liver steatosis in patients with Type II diabetes [J].

Bernard, S ;

Touzet, S ;

Personne, I ;

Lapras, V ;

Bondon, PJ ;

Berthezène, F ;

Moulin, P .

DIABETOLOGIA, 2000, 43 (08) :995-999

[10]

Elevated Expression of Osteopontin May Be Related to Adipose Tissue Macrophage Accumulation and Liver Steatosis in Morbid Obesity [J].

Bertola, Adeline ;

Deveaux, Vanessa ;

Bonnafous, Stephanie ;

Rousseau, Deborah ;

Anty, Rodolphe ;

Wakkach, Abdelilah ;

Dahman, Moncef ;

Tordjman, Joan ;

Clement, Karine ;

McQuaid, Siobhan E. ;

Frayn, Keith N. ;

Huet, Pierre-Michel ;

Gugenheim, Jean ;

Lotersztajn, Sophie ;

Le Marchand-Brustel, Yannick ;

Tran, Albert ;

Gual, Philippe .

DIABETES, 2009, 58 (01) :125-133

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