Prolyl 4-hydroxylase inhibitor (HOE 077) prevents TIMP-1 gene expression in rat liver fibrosis

被引：41

作者：

Sakaida, I ^{[1
]}

Uchida, K ^{[1
]}

Hironaka, K ^{[1
]}

Okita, K ^{[1
]}

机构：

[1] Yamaguchi Univ, Sch Med, Dept Internal Med 1, Ube, Yamaguchi 7558505, Japan

来源：

JOURNAL OF GASTROENTEROLOGY | 1999年 / 34卷 / 03期

关键词：

prolyl 4-hydroxylase inhibitor; procollagen; tissue inhibitor of metalloproteinase-1 (TIMP-1);

D O I：

10.1007/s005350050277

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The effects of a prolyl 4-hydroxylase inhibitor (HOE 077) on tissue inhibitor of metalloproteinase-l (TIMP-1) and procollagen type I were examined in rat liver fibrosis. HOE 077 (200 ppm) prevented fibrosis by inhibiting the expression of liver type I procollagen and TIMP-1 mRNAs, with liver hydroxyroline content correlated with the reduction in activated stellate cells. HOE 077 prevents fibrosis by inhibiting proline hydroxylation and stellate cell activation, resulting in reduced expression of procollagen and TIMP-1 mRNAs.

引用

页码：376 / 377

页数：2

共 8 条

[1]

FRIEDMAN SL, 1993, NEW ENGL J MED, V328, P1828

[2]

PROLYL 4-HYDROXYLASE, A TARGET ENZYME FOR DRUG DEVELOPMENT - DESIGN OF SUPPRESSIVE AGENTS AND THE INVITRO EFFECTS OF INHIBITORS AND PROINHIBITORS [J].