Synthesis and applications of a fluorous THP protective group

被引：54

作者：

Wipf, P ^{[1
]}

Reeves, JT ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 25期

关键词：

D O I：

10.1016/S0040-4039(99)00866-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A recyclable fluorous labeled THP protecting group has been developed that allows for simple purification of small molecules by liquid-liquid extraction with FC-72/MeCN, and of larger or more polar molecules by solid phase extraction with fluorous reverse phase silica gel. In addition, we report a new glycosylation method which uses the Cp2ZrCl2-AgClO4 reagent system to activate an anomeric sulfoxide. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：4649 / 4652

页数：4

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