Phagocytic signaling strategies:: Fcγ receptor-mediated phagocytosis as a model system

被引：75

作者：

Cox, D

Greenberg, S

机构：

[1] Columbia Univ, Dept Med, New York, NY 10032 USA

[2] Columbia Univ, Dept Pharmacol, New York, NY 10032 USA

来源：

SEMINARS IN IMMUNOLOGY | 2001年 / 13卷 / 06期

基金：

美国国家卫生研究院;

关键词：

actin; Fc(gamma) receptors; Syk; tyrosine kinase;

D O I：

10.1006/smim.2001.0330

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Phagocytosis is a phylogenetically ancient process by which eukaryotic cells engulf insoluble substances whose size exceeds approximately 0.5 mum. The engulfment process requires the concerted action of several fundamental cellular pathways and is governed by multiple transmembrane signaling events. Here we focus on phagocytosis mediated by a well-studied class of phagocytic receptors that recognize the Fc portion of IgG (Fc(gamma)Rs).

引用

收藏

页码：339 / 345

页数：7

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