NMDA receptor encephalitis and other antibody-mediated disorders of the synapse The 2016 Cotzias Lecture

被引：178

作者：

Dalmau, Josep ^{[1
,2
,3
]}

机构：

[1] Univ Barcelona, Hosp Clin IDIBAPS, Serv Neurol, Barcelona, Spain

[2] Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain

[3] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

来源：

NEUROLOGY | 2016年 / 87卷 / 23期

关键词：

D-ASPARTATE RECEPTOR; HERPES-SIMPLEX ENCEPHALITIS; CASE SERIES; GABA(A) RECEPTOR; PLASMA-CELLS; AUTOANTIBODIES; MECHANISMS; SCHIZOPHRENIA; DIAGNOSIS; GLUTAMATE;

D O I：

10.1212/WNL.0000000000003414

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Investigations during the last 10 years have revealed a group of disorders mediated by antibodies against ion channels and synaptic receptors, which cause both neurologic and psychiatric symptoms. In this review, I discuss the process of discovery and immunologic triggers of these disorders, and use anti-NMDA receptor encephalitis to emphasize the importance of understanding the underlying physiopathologic mechanisms in those diseases. A better knowledge of these mechanisms reveals points of convergence with other disorders (e.g., schizophrenia), suggests treatment strategies beyond immunotherapy, and is helping us understand how memories are formed and retrieved.

引用

页码：2471 / 2482

页数：12

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