Hsp27: Novel regulator of intracellular redox state

被引：153

作者：

Arrigo, AP ^{[1
]}

机构：

[1] Univ Lyon 1, CNRS, UMR 5534,Ctr Genet Mol & Cellulaire, Lab Stress Oxydant Chaperons & Apoptose, F-69622 Villeurbanne, France

来源：

IUBMB LIFE | 2001年 / 52卷 / 06期

关键词：

D O I：

10.1080/152165401317291156

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Small stress proteins are molecular chaperones that modulate the ability of cells to respond to several types of injuries. In this regard, a protection generated by the expression of mammalian small stress proteins against the cell death induced by oxidative stress has been described. This review summarizes the current knowledge of the protective mechanism generated by the expression of the major mammalian small stress protein Hsp27 in cells exposed to oxidative stress. A possible role of this chaperon protein in the presentation of oxidized proteins to the proteasome degradation machinery is proposed.

引用

页码：303 / 307

页数：5

共 63 条

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