Health-related Quality of Life in Patients with Brain Tumors: Limitations and Additional Outcome Measures

被引：31

作者：

Dirven, Linda ^{[1
]}

Reijneveld, Jacob C. ^{[1
]}

Aaronson, Neil K. ^{[2
]}

Bottomley, Andrew ^{[3
]}

Uitdehaag, Bernard M. J. ^{[1
,4
]}

Taphoorn, Martin J. B. ^{[1
,5
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, Dept Neurol, NL-1007 MB Amsterdam, Netherlands

[2] Netherlands Canc Inst, Div Psychosocial Res & Epidemiol, Amsterdam, Netherlands

[3] European Org Res Treatment Canc, Qual Life Dept, Brussels, Belgium

[4] Vrije Univ Amsterdam Med Ctr, Dept Epidemiol & Biostat, NL-1007 MB Amsterdam, Netherlands

[5] Med Ctr Haaglanden, Dept Neurol, The Hague, Netherlands

来源：

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS | 2013年 / 13卷 / 07期

关键词：

Health-related quality of life; Brain tumors; Methodological limitations; Missing data; Response shift; Differential item functioning; Cognitive deterioration; CANCER CLINICAL-TRIALS; CELL LUNG-CANCER; RESPONSE SHIFT; SIGNIFICANT OTHERS; EORTC QLQ-C30; EUROPEAN-ORGANIZATION; METHODOLOGICAL ISSUES; FUNCTIONAL ASSESSMENT; CARE PROVIDERS; ADULT PATIENTS;

D O I：

10.1007/s11910-013-0359-y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Health-related quality of life (HRQOL) is a multidimensional concept used to measure patients' functioning and well-being. In recent decades, HRQOL has become an important (secondary) outcome measure in clinical trials for brain tumor patients. It could be questioned, however, whether HRQOL is the only useful outcome measure for assessing the level of functioning and well-being of these patients. As described in this review, several general methodological issues can hamper the interpretation of HRQOL data collected in the oncology setting. Additionally, because brain tumor patients have a progressive brain disease resulting in cognitive impairments, patient-reported outcomes may not always be the most informative and accurate measures of HRQOL in brain tumor patients. Supplementary or alternative measures, such as proxy-rated HRQOL measures and measures of instrumental activities of daily living, may provide a more complete picture of brain tumor patients' functioning in daily life.

引用

页数：9

共 95 条

[1]

Aaronson N K, 1988, Oncology (Williston Park), V2, P69

[2]

Compromised Health-Related Quality of Life in Patients With Low-Grade Glioma [J].