Brain network dysfunction in bipolar disorder

被引:78
作者
Adler, CM [1 ]
DelBello, MP [1 ]
Strakowski, SM [1 ]
机构
[1] Univ Cincinnati, Coll Med, Dept Psychiat, Div Bipolar Disorders Res, Cincinnati, OH 45267 USA
关键词
D O I
10.1017/S1092852900020800
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Bipolar disorder is a common psychiatric condition with significant associated morbidity and mortality. Despite its significance, the neurophysiology and neuropathology of this illness is incompletely understood. Recent advances in neuroimaging techniques have helped to begin clarifying these areas. Specifically, bipolar disorder appears to arise from abnormalities within discrete brain networks (eg, the anterior limbic network). The expression of the symptoms of bipolar disorder does not appear to result from single, localized brain lesions, but rather are emergent properties of dysfunction of these brain networks. As neuroimaging techniques continue to improve, the underlying neural basis of bipolar disorder will be clarified.
引用
收藏
页码:312 / 320
页数:9
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