VmrA, a member of a novel class of Na+-coupled multidrug efflux pumps from Vibrio parahaemolyticus

被引：105

作者：

Chen, J ^{[1
]}

Morita, Y ^{[1
]}

Huda, MN ^{[1
]}

Kuroda, T ^{[1
]}

Mizushima, T ^{[1
]}

Tsuchiya, T ^{[1
]}

机构：

[1] Okayama Univ, Fac Pharmaceut Sci, Dept Microbiol, Okayama 7008530, Japan

来源：

JOURNAL OF BACTERIOLOGY | 2002年 / 184卷 / 02期

关键词：

D O I：

10.1128/JB.184.2.572-576.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Gene vmrA, cloned from Vibrio parahaemolyticus, made Escherichia coli resistant to 4',6-diamino-2-phenylindol, tetraphenylphosphonium chloride, acriflavine, and ethidium bromide. VmrA belongs to the DinF branch of MATE family efflux transporters. VmrA catalyzed acriflavine efflux and showed Na+/drug transporter activity because the addition of tetraphenylphosphonium to Na+-loaded cells caused Na+ efflux.

引用

页码：572 / 576

页数：5

共 28 条

[1] [Anonymous], 1984, BERGEYS MANUAL SYSTE
[2] POLAR AND LATERAL FLAGELLAR MOTORS OF MARINE VIBRIO ARE DRIVEN BY DIFFERENT ION-MOTIVE FORCES
ATSUMI, T
MCCARTER, L
IMAE, Y
[J]. NATURE, 1992, 355 (6356) : 182 - 184
[3] ISOLATION OF HIGH MOLECULAR WEIGHT DNA FROM HEMOPHILUS INFLUENZAE
BERNS, KI
THOMAS, CA
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1965, 11 (03) : 476 - &
[4] The multidrug efflux protein NorM is a prototype of a new family of transporters
Brown, MH
Paulsen, IT
Skurray, RA
[J]. MOLECULAR MICROBIOLOGY, 1999, 31 (01) : 394 - 395
[5] ANALYSIS OF MEMBRANE AND SURFACE PROTEIN SEQUENCES WITH THE HYDROPHOBIC MOMENT PLOT
EISENBERG, D
SCHWARZ, E
KOMAROMY, M
WALL, R
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1984, 179 (01) : 125 - 142
[6] STUDIES ON TRANSFORMATION OF ESCHERICHIA-COLI WITH PLASMIDS
HANAHAN, D
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1983, 166 (04) : 557 - 580
[7] DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae
Heidelberg, JF
Eisen, JA
Nelson, WC
Clayton, RA
Gwinn, ML
Dodson, RJ
Haft, DH
Hickey, EK
Peterson, JD
Umayam, L
Gill, SR
Nelson, KE
Read, TD
Tettelin, H
Richardson, D
Ermolaeva, MD
Vamathevan, J
Bass, S
Qin, HY
Dragoi, I
Sellers, P
McDonald, L
Utterback, T
Fleishmann, RD
Nierman, WC
White, O
Salzberg, SL
Smith, HO
Colwell, RR
Mekalanos, JJ
Venter, JC
Fraser, CM
[J]. NATURE, 2000, 406 (6795) : 477 - 483
[8] TRANSDUCTION OF LINKED GENETIC CHARACTERS OF THE HOST BY BACTERIOPHAGE-PL
LENNOX, ES
[J]. VIROLOGY, 1955, 1 (02) : 190 - 206
[9] Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli: Application to open reading frame characterization
Link, AJ
Phillips, D
Church, GM
[J]. JOURNAL OF BACTERIOLOGY, 1997, 179 (20) : 6228 - 6237
[10] GENES ACRA AND ACRB ENCODE A STRESS-INDUCED EFFLUX SYSTEM OF ESCHERICHIA-COLI
MA, D
COOK, DN
ALBERTI, M
PON, NG
NIKAIDO, H
HEARST, JE
[J]. MOLECULAR MICROBIOLOGY, 1995, 16 (01) : 45 - 55

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