The rapid efficacy of abatacept in a patient with rheumatoid vasculitis

被引：14

作者：

Fujii, Wataru ^{[1
]}

Kohno, Masataka ^{[1
]}

Ishino, Hidetaka ^{[1
]}

Nakabayashi, Amane ^{[1
]}

Fujioka, Kazuki ^{[1
]}

Kida, Takashi ^{[1
]}

Nagahara, Hidetake ^{[1
]}

Murakami, Ken ^{[1
]}

Nakamura, Kaoru ^{[1
]}

Seno, Takahiro ^{[1
]}

Yamamoto, Aihiro ^{[1
]}

Kawahito, Yutaka ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, Japan

来源：

MODERN RHEUMATOLOGY | 2012年 / 22卷 / 04期

关键词：

Abatacept; Cytotoxic T lymphocyte-associated antigen 4 (CTLA4); Rheumatoid vasculitis; ANCA-ASSOCIATED VASCULITIS; WEGENERS-GRANULOMATOSIS; ARTHRITIS; CYCLOPHOSPHAMIDE; RITUXIMAB; ASSOCIATION; INFLIXIMAB; DISEASE; CTLA-4; GENES;

D O I：

10.1007/s10165-011-0559-8

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

We report a case of rheumatoid vasculitis (RV) that responded well to abatacept, a cytotoxic T lymphocyte-associated antigen 4 (CTLA4)-immunoglobulin fusion protein. A 38-year-old woman developed RV despite treatment with methotrexate and tumor necrosis factor (TNF) inhibitors. The effects of steroid therapy, immunoabsorption plasmapheresis, and interleukin-6 inhibitor were insufficient, however, administration of abatacept rapidly improved her clinical symptoms with almost normalization of the immunological findings. This is the first published case report of the successful treatment of RV with abatacept.

引用

页码：630 / 634

页数：5

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