Metal-saccharide chemistry and biology: Saccharide complexes of zinc and their effect on metallothionein synthesis in mice

被引：33

作者：

Bandwar, RP

Giralt, M

Hidalgo, J

Rao, CP

机构：

[1] INDIAN INST TECHNOL, DEPT CHEM, BIOINORGAN LAB, BOMBAY 400076, MAHARASHTRA, INDIA

[2] UNIV AUTONOMA BARCELONA, FAC CIENCIES, DEPT BIOL CELULAR & FISIOL, UNIDAD FISIOL ANIM, E-08193 BARCELONA, SPAIN

来源：

CARBOHYDRATE RESEARCH | 1996年 / 284卷 / 01期

关键词：

complex; metal-saccharide; zinc-saccharide complex; metallothionein;

D O I：

10.1016/0008-6215(96)00009-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Monosaccharide (D-Fru, D-Gal, D-Glc, D-Xyl, and D-Rib) and disaccharide (Mal) complexes of Zn2+ were synthesised using different precursors and isolated in the solid state, These were found to be anionic with a Zn-to-saccharide ratio of 1:1 and 2:1 for monosaccharide and disaccharide complexes, respectively. Electrochemical behaviour in aqueous solution was studied by extensive cyclic voltammetric studies in the pH range 3.7-10.3. The effect of subcutaneously injected Zn-D-Fru, Zn-D-Gal and Zn-D-Glc complexes on the metallothionein synthesis in mice was found to be significant in the liver, but not in the brain.

引用

页码：73 / 84

页数：12

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