Interaction of human immunodeficiency virus-derived vectors with wild-type virus in transduced cells

被引：94

作者：

Bukovsky, AA ^{[1
]}

Song, JP ^{[1
]}

Naldini, L ^{[1
]}

机构：

[1] Cell Genesys, Foster City, CA 94404 USA

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 08期

关键词：

D O I：

10.1128/JVI.73.8.7087-7092.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The interaction of human immunodeficiency virus (HIV)-derived vectors with wild-type virus was analyzed in transduced cells. Vector transcripts upregulated by infection had no measurable effect on HIV type 1 (HIV-1) expression but competed efficiently for encapsidation, inhibiting the infectivity and spread of HIV-1 in culture and leading to mobilization and recombination of the vector. These effects were abrogated with a self-inactivating vector.

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页码：7087 / 7092

页数：6

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