More excited for negative facial expressions in depression: Evidence from an event-related potential study

被引:68
作者
Dai, Qin [1 ]
Feng, Zhengzhi [1 ]
机构
[1] Third Mil Med Univ, Educ Ctr Mental Hlth, Chongqing 400038, Peoples R China
关键词
Depression; Intensity; Evaluation; Emotional faces; SELECTIVE ATTENTION; IMPAIRED DISENGAGEMENT; EMOTIONAL INTENSITY; BIAS; PERCEPTION; ANXIETY; COMPONENTS; DYSPHORIA; RESPONSES; JUDGMENT;
D O I
10.1016/j.clinph.2012.04.018
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: This study aims to investigate the intensity evaluation of social stimuli in depression. Methods: Twenty-four never-disordered control participants (NC), 24 sub-clinically depressed individuals and 24 participants diagnosed with a current major depressive disorder (MDD) were recruited. All participants completed an emotional intensity evaluation task, in which they were required to judge the intensity of the facial expressions by pressing response keys, with the event-related potential (ERP) being recorded during the process. Results: The MDD participants had higher intensity scores for sad faces compared with the NC group, longer reaction times (RTs) for all faces compared with other groups and higher P1 and P2 amplitude for sad faces compared with other faces. The sub-clinically depressed individuals had lower intensity scores for happy and neutral faces compared with other groups, longer RTs for happy faces compared with other faces and higher P1 and P2 amplitudes for happy faces compared with sad faces. Conclusion: The findings suggest that the MDD participants are more excited for negative facial expressions, while the sub-clinically depressed individuals might have a disturbed perception for happy stimuli, which suggests a different cognitive pattern for facial expressions between MDD and sub-clinical depression. Moreover, the deep perception for sad faces is correlated with increased suicidal ideation. Significance: The intensity effect of social stimuli (facial expressions) was observed in sub-clinically and clinically depressed (MDD) individuals simultaneously, which might suggest that the more excited perception for negative facial expressions is a stable cognitive vulnerability possibly associated with the occurrence or recurrence of depression. (C) 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:2172 / 2179
页数:8
相关论文
共 50 条
[1]  
[Anonymous], Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Non-patient Edition
[2]   Attentional bias training in depression: Therapeutic effects depend on depression severity [J].
Baert, Saskia ;
De Raedt, Rudi ;
Schacht, Rik ;
Koster, Ernst H. W. .
JOURNAL OF BEHAVIOR THERAPY AND EXPERIMENTAL PSYCHIATRY, 2010, 41 (03) :265-274
[3]   AN INVENTORY FOR MEASURING CLINICAL ANXIETY - PSYCHOMETRIC PROPERTIES [J].
BECK, AT ;
BROWN, G ;
EPSTEIN, N ;
STEER, RA .
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY, 1988, 56 (06) :893-897
[4]  
Beck AT., 1996, MANUAL BECK DEPRESSI, V1, P82, DOI DOI 10.1037/T00742-000
[5]   Electrophysiological studies of face perception in humans [J].
Bentin, S ;
Allison, T ;
Puce, A ;
Perez, E ;
McCarthy, G .
JOURNAL OF COGNITIVE NEUROSCIENCE, 1996, 8 (06) :551-565
[6]   Sustained attention deficits in manic and euthymic patients with bipolar disorder [J].
Bora, Emre ;
Vahip, Simavi ;
Akdeniz, Fisun .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2006, 30 (06) :1097-1102
[7]   Brain activation to emotional words in depressed vs healthy subjects [J].
Canli, T ;
Sivers, H ;
Thomason, ME ;
Whitfield-Gabrieli, S ;
Gabrieli, JDE ;
Gotlib, IH .
NEUROREPORT, 2004, 15 (17) :2585-2588
[8]   Mood effects on the ERP processing of emotional intensity in faces: A P3 investigation with depressed students [J].
Cavanagh, J ;
Geisler, MW .
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 2006, 60 (01) :27-33
[9]   Substance abuse-related P300 differences in response to an implicit memory task [J].
Ceballos, NA ;
Nixon, SJ ;
Tivis, R .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2003, 27 (01) :157-164
[10]   Deficient distracter inhibition and enhanced facilitation for emotional stimuli in depression: An ERP study [J].
Dai, Qin ;
Feng, Zhengzhi ;
Koster, Ernst H. W. .
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 2011, 79 (02) :249-258