Relationship between cerebral microbleeds and cognitive function in lacunar infarct

被引：56

作者：

Zhang, Min ^{[1
,2
]}

Chen, Maogang ^{[3
]}

Wang, Qizhang ^{[4
]}

Yun, Wenwei ^{[1
]}

Zhang, Zhizhong ^{[2
]}

Yin, Qin ^{[2
]}

Huang, Qinsong ^{[2
]}

Zhu, Wusheng ^{[2
]}

机构：

[1] Nanjing Med Univ, Second Peoples Hosp Changzhou, Dept Neurol, Changzhou 213000, Jiangsu, Peoples R China

[2] Nanjing Univ, Jinling Hosp, Dept Neurol, Sch Med, Nanjing 210002, Jiangsu, Peoples R China

[3] Nantong Univ, Affiliated Hosp 4, Yancheng City Peoples Hosp 1, Dept Neurol, Yancheng City, Jiangsu, Peoples R China

[4] Guangzhou Med Univ, Shajing Peoples Hosp, Affiliated Shenzhen Shajing Hosp, Dept Neurol, Guangzhou, Guangdong, Peoples R China

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2013年 / 41卷 / 02期

关键词：

Cerebral microbleed; cognition; ischaemic stroke; lacunar infarct; SMALL VESSEL DISEASE; RISK-FACTORS; STROKE RECURRENCE; ISCHEMIC STROKE; ROTTERDAM SCAN; SIGNAL LOSS; MRI; IMPAIRMENT; BRAIN; LEUKOARAIOSIS;

D O I：

10.1177/0300060513476448

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Objective: Little is known about the impact of cerebral microbleeds on cognitive function. This study investigated the distribution of cerebral microbleeds and their impact on cognitive function, in patients with lacunar infarct. Methods: Patients with lacunar infarct were enrolled prospectively. Cerebral microbleeds were classified as absent, mild, moderate or severe, based on magnetic resonance imaging findings. Cognitive function was measured using the Montreal Cognitive Assessment (MoCA) questionnaire, with a total score of <26 indicating cognitive impairment. Results: Of the 85 patients included in the study, 35 (41.2%) had cerebral microbleeds. They were more frequently observed in mixed and deep brain regions, but rarely in the cerebral lobes. Multiple logistic regression analysis demonstrated that presence of cerebral microbleeds (odds ratio [OR] 5.320), duration of education (OR 0.938) and age (OR 1.464) were independent predictors of cognitive impairment. There was a significant correlation between cerebral microbleed severity and MoCA score. Conclusion: The number and location of cerebral microbleeds were both closely associated with cognitive impairment, in patients with lacunar infarct.

引用

页码：347 / 355

页数：9

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