Scavenger receptors in homeostasis and immunity

被引：606

作者：

Canton, Johnathan ^{[1
]}

Neculai, Dante ^{[1
]}

Grinstein, Sergio ^{[1
,2
,3
]}

机构：

[1] Hosp Sick Children, Cell Biol Program, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Dept Biochem, Toronto, ON M5G 1X8, Canada

[3] St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON M5B 1W8, Canada

来源：

NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 09期

基金：

加拿大健康研究院;

关键词：

HIGH-DENSITY-LIPOPROTEIN; B TYPE-I; RETINAL-PIGMENT EPITHELIUM; PROTEIN-TYROSINE KINASES; CYSTEINE-RICH DOMAIN; HUMAN P2X7 RECEPTOR; SR-BI; INNATE IMMUNITY; CRYSTAL-STRUCTURE; APOPTOTIC CELLS;

D O I：

10.1038/nri3515

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Scavenger receptors were originally identified by their ability to recognize and to remove modified lipoproteins; however, it is now appreciated that they carry out a striking range of functions, including pathogen clearance, lipid transport, the transport of cargo within the cell and even functioning as taste receptors. The large repertoire of ligands recognized by scavenger receptors and their broad range of functions are not only due to the wide range of receptors that constitute this family but also to their ability to partner with various co-receptors. The ability of individual scavenger receptors to associate with different co-receptors makes their responsiveness extremely versatile. This Review highlights recent insights into the structural features that determine the function of scavenger receptors and the emerging role that these receptors have in immune responses, notably in macrophage polarization and in the pathogenesis of diseases such as atherosclerosis and Alzheimer's disease.

引用

页码：621 / 634

页数：14

共 223 条

[1] The transmembrane CXC-chemokine ligand 16 is induced by IFN-γ and TNF-α and shed by the activity of the disintegrin-like metalloproteinase ADAM10 [J].

Abel, S ;

Hundhausen, C ;

Mentlein, R ;

Schulte, A ;

Berkhout, TA ;

Broadway, N ;

Hartmann, D ;

Sedlacek, R ;

Dietrich, S ;

Muetze, B ;

Schuster, B ;

Kallen, KJ ;

Saftig, P ;

Rose-John, S ;

Ludwig, A .

JOURNAL OF IMMUNOLOGY, 2004, 172 (10) :6362-6372

[2] Identification of scavenger receptor SR-BI as a high density lipoprotein receptor [J].

Acton, S ;

Rigotti, A ;

Landschulz, KT ;

Xu, SZ ;

Hobbs, HH ;

Krieger, M .

SCIENCE, 1996, 271 (5248) :518-520

[3] The origin of circulating CD36 in type 2 diabetes [J].

Alkhatatbeh, M. J. ;

Enjeti, A. K. ;

Acharya, S. ;

Thorne, R. F. ;

Lincz, L. F. .

NUTRITION & DIABETES, 2013, 3 :e59-e59

[4] Aberrant expression of CD6 on B-cell subsets from patients with Sjogren's syndrome [J].

Alonso, Ruby ;

Buors, Caroline ;

Le Dantec, Christelle ;

Hillion, Sophie ;

Pers, Jacques-Olivier ;

Saraux, Alain ;

Montero, Enrique ;

Marianowski, Remi ;

Loisel, Severine ;

Devauchelle, Valerie ;

Youinou, Pierre ;

Renaudineau, Yves .

JOURNAL OF AUTOIMMUNITY, 2010, 35 (04) :336-341

[5] Pivotal Advance: Toll-like receptor regulation of scavenger receptor-A-mediated phagocytosis [J].

Amiel, Eyal ;

Alonso, Anselmo ;

Uematsu, Satoshi ;

Akira, Shizuo ;

Poynter, Matthew E. ;

Berwin, Brent .

JOURNAL OF LEUKOCYTE BIOLOGY, 2009, 85 (04) :595-605

[6] Multinucleated giant cells [J].

Anderson, JM .

CURRENT OPINION IN HEMATOLOGY, 2000, 7 (01) :40-47

[7] Functional changes in scavenger receptor binding conformation are induced by charge mutants spanning the entire collagen domain [J].

Andersson, L ;

Freeman, MW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (31) :19592-19601

[8]

Areschoug Thomas, 2008, V15, P45, DOI 10.1159/000135685

[9] Scavenger receptors: role in innate immunity and microbial pathogenesis [J].

Areschoug, Thomas ;

Gordon, Siamon .

CELLULAR MICROBIOLOGY, 2009, 11 (08) :1160-1169

[10]

Aronow Wilbert S., 2004, Current Drug Targets - Cardiovascular & Haematological Disorders, V4, P265, DOI 10.2174/1568006043336104

← 1 2 3 4 5 6 7 8 9 10 →