Cyclic di-GMP as a second messenger

被引：275

作者：

Römling, U

Amikam, D

机构：

[1] Karolinska Inst, Microbiol & Tumor Biol Ctr, SE-17177 Stockholm, Sweden

[2] Hadassah Univ, Med Ctr, Sharett Inst Oncol, Jerusalem, Israel

[3] Tel Hai Acad Coll, Dept Biotechnol & Environm Sci, Tel Hai, Israel

来源：

CURRENT OPINION IN MICROBIOLOGY | 2006年 / 9卷 / 02期

关键词：

D O I：

10.1016/j.mib.2006.02.010

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In many bacteria bis-(3',5)-cyclic dimeric guanosine monophosphate (c-di-GMP) signaling determines the timing and amplitude of complex biological processes from biofilm formation and virulence to photosynthesis. Thereby, the tightly regulated temporal and spatial activity patterns of GGDEF and EAL domain proteins, which synthesize and degrade c-di-GMP, respectively, are currently being resolved. Although details of the mechanisms of c-di-GMP signaling are not yet determined, the recent presentation of PilZ as a candidate c-di-GMP binding-domain opens the field for experimental investigations. Besides its role as an intracellular signaling molecule in bacteria, c-di-GMP also acts as an intercellular signaling molecule between prokaryotes and also has effects in eukaryotes that could provide a perspective in cancer treatment.

引用

收藏

页码：218 / 228

页数：11

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