Frequency and treatment of depressive symptoms in a Parkinson's disease registry

被引：38

作者：

Althaus, Astrid ^{[1
,2
]}

Arranz Becker, Oliver ^{[3
]}

Spottke, Annika ^{[4
]}

Dengler, Reinhard ^{[5
]}

Schneider, Frank ^{[2
]}

Kloss, Manja ^{[6
]}

Eggert, Karla ^{[1
]}

Oertel, Wolfgang H. ^{[1
]}

Dillmann, Ulrich

Herting, Birgit ^{[7
]}

Classen, Joseph ^{[8
,9
]}

Dodel, Richard ^{[1
]}

机构：

[1] Univ Marburg, Dept Neurol, D-35032 Marburg, Germany

[2] Rhein Westfal TH Aachen, Dept Psychiat & Psychotherapy, Aachen, Germany

[3] Rhein Westfal TH Aachen, Inst Sociol, Aachen, Germany

[4] Univ Bonn, Dept Neurol, D-5300 Bonn, Germany

[5] Hannover Med Sch, Neurol Clin, D-3000 Hannover, Germany

[6] Heidelberg Univ, Neurol Clin, Heidelberg, Germany

[7] Tech Univ Dresden, Dept Neurol, Dresden, Germany

[8] Bavarian Julius Maximilians Univ, Neurol Univ Clin, Wurzburg, Germany

[9] Bavarian Julius Maximilians Univ, Outpatient Clin, Wurzburg, Germany

来源：

PARKINSONISM & RELATED DISORDERS | 2008年 / 14卷 / 08期

关键词：

Parkinson's disease; Depression; Antidepressants; MADRS;

D O I：

10.1016/j.parkreldis.2008.01.016

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose of this cross-sectional study was to estimate the occurrence of depressive symptoms, as related to other clinical data, in a sample of Parkinson's disease (PD) patients (n = 226). Furthermore, we examined the medical care of depressive symptoms in this sample. H&Y stages, cognitive status, sleeping disorders, and dysphagia resulted as significant predictors for depression. Prevalence of depressive symptoms was 35.4%. Only 25.0% of patients suffering from moderate to severe depressive symptoms were prescribed antidepressants. This study supports the view that depression may be underrecognized and undertreated in PD patients. A significant proportion of patients continues to experience depressive symptoms despite antidepressive medication. Recognition and treatment of depression remains a challenge for management of PD. Possible coexisting depressive symptoms should be revealed and assessed by standardized interviews in everyday clinical routine. Large scale randomized controlled trials examining efficacy and safety of antidepressants in PD patients are urgently required. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：626 / 632

页数：7

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