Synthetic biology: advancing biological frontiers by building synthetic systems

被引：54

作者：

Chen, Yvonne Y. ^{[2
,3
]}

Galloway, Kate E. ^{[4
]}

Smolke, Christina D. ^{[1
]}

机构：

[1] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

[2] Harvard Univ, Cambridge, MA 02138 USA

[3] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA

[4] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA

来源：

GENOME BIOLOGY | 2012年 / 13卷 / 02期

基金：

美国国家卫生研究院;

关键词：

MAMMALIAN-CELLS; GENE-EXPRESSION; SACCHAROMYCES-CEREVISIAE; STEM-CELLS; RECOMBINATION CLONING; TRANSGENE EXPRESSION; CELLULAR INFORMATION; PROTEIN-DEGRADATION; CHEMICAL-SYNTHESIS; ESCHERICHIA-COLI;

D O I：

10.1186/gb-2012-13-2-240

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Advances in synthetic biology are contributing to diverse research areas, from basic biology to biomanufacturing and disease therapy. We discuss the theoretical foundation, applications, and potential of this emerging field.

引用

页数：10

共 93 条

[1] Rational design of memory in eukaryotic cells [J].

Ajo-Franklin, Caroline M. ;

Drubin, David A. ;

Eskin, Julian A. ;

Gee, Elaine P. S. ;

Landgraf, Dirk ;

Phillips, Ira ;

Silver, Pamela A. .

GENES & DEVELOPMENT, 2007, 21 (18) :2271-2276

[2] Tuning genetic control through promoter engineering [J].

Alper, H ;

Fischer, C ;

Nevoigt, E ;

Stephanopoulos, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (36) :12678-12683

[3] Artificial control of gene expression in mammalian cells by modulating RNA interference through aptamer-small molecule interaction [J].

An, CI ;

Trinh, VB ;

Yokobayashi, Y .

RNA, 2006, 12 (05) :710-716

[4]

[Anonymous], 2003, IDEMPOTENT VECTOR DE

[5] Programmable Ligand Detection System in Plants through a Synthetic Signal Transduction Pathway [J].

Antunes, Mauricio S. ;

Morey, Kevin J. ;

Smith, J. Jeff ;

Albrecht, Kirk D. ;

Bowen, Tessa A. ;

Zdunek, Jeffrey K. ;

Troupe, Jared F. ;

Cuneo, Matthew J. ;

Webb, Colleen T. ;

Hellinga, Homme W. ;

Medford, June I. .

PLOS ONE, 2011, 6 (01)

[6] Synthetic RNA modules for fine-tuning gene expression levels in yeast by modulating RNase III activity [J].

Babiskin, Andrew H. ;

Smolke, Christina D. .

NUCLEIC ACIDS RESEARCH, 2011, 39 (19) :8651-8664

[7] A synthetic library of RNA control modules for predictable tuning of gene expression in yeast [J].

Babiskin, Andrew H. ;

Smolke, Christina D. .

MOLECULAR SYSTEMS BIOLOGY, 2011, 7

[8] Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics [J].

Bashor, Caleb J. ;

Helman, Noah C. ;

Yan, Shude ;

Lim, Wendell A. .

SCIENCE, 2008, 319 (5869) :1539-1543

[9] A synthetic multicellular system for programmed pattern formation [J].

Basu, S ;

Gerchman, Y ;

Collins, CH ;

Arnold, FH ;

Weiss, R .

NATURE, 2005, 434 (7037) :1130-1134

[10] Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing [J].

Beisel, Chase L. ;

Chen, Yvonne Y. ;

Culler, Stephanie J. ;

Hoff, Kevin G. ;

Smolke, Christina D. .

NUCLEIC ACIDS RESEARCH, 2011, 39 (07) :2981-2994

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