The structural basis for the sensing and binding of cyclic di-GMP by STING

被引：175

作者：

Huang, Yi-He ^{[1
,2
,3
]}

Liu, Xiang-Yu ^{[1
,2
]}

Du, Xiao-Xia ^{[1
,2
,3
]}

Jiang, Zheng-Fan ^{[1
]}

Su, Xiao-Dong ^{[1
,2
]}

机构：

[1] Peking Univ, Sch Life Sci, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China

[2] Peking Univ, Sch Life Sci, Biodynam Opt Imaging Ctr BIOP, Beijing 100871, Peoples R China

[3] Peking Univ, Shenzhen Grad Sch, Shenzhen, Peoples R China

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2012年 / 19卷 / 07期

关键词：

INNATE; ADAPTER; REVEALS; MPYS;

D O I：

10.1038/nsmb.2333

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

STING (stimulator of interferon genes) is an essential signaling adaptor that mediates cytokine production in response to microbial invasion by directly sensing bacterial secondary messengers such as the cyclic dinucleotide bis-(3'-5')-cyclic dimeric GMP (c-di-GMP). STING's structure and its binding mechanism to cyclic dinucleotides were unknown. We report here the crystal structures of the STING cytoplasmic domain and its complex with c-di-GMP, thus providing the structural basis for understanding STING function.

引用

页码：728 / +

页数：4

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