Benefits and risks of tight glucose control in critically ill adults - A meta-analysis

被引:702
作者
Soylemez Wiener, Renda [1 ,2 ]
Wiener, Daniel C. [3 ]
Larson, Robin J. [1 ,2 ]
机构
[1] Dept Vet Affairs Med Ctr, VA Outcomes Grp, White River Jct, VT 05009 USA
[2] Dartmouth Med Sch, Dartmouth Inst Hlth Policy & Clin Practice, Hanover, NH USA
[3] Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA
来源
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 2008年 / 300卷 / 08期
关键词
D O I
10.1001/jama.300.8.933
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Context The American Diabetes Association and Surviving Sepsis Campaign recommend tight glucose control in critically ill patients based largely on 1 trial that shows decreased mortality in a surgical intensive care unit. Because similar studies report conflicting results and tight glucose control can cause dangerous hypoglycemia, the data underlying this recommendation should be critically evaluated. Objective To evaluate benefits and risks of tight glucose control vs usual care in critically ill adult patients. Data Sources MEDLINE ( 1950- 2008), the Cochrane Library, clinical trial registries, reference lists, and abstracts from conferences from both the American Thoracic Society ( 2001- 2008) and the Society of Critical Care Medicine ( 2004- 2008). Study Selection We searched for studies in any language in which adult intensive care patients were randomly assigned to tight vs usual glucose control. Of 1358 identified studies, 34 randomized trials ( 23 full publications, 9 abstracts, 2 unpublished studies) met inclusion criteria. Data Extraction and Analysis Two reviewers independently extracted information using a prespecified protocol and evaluated methodological quality with a standardized scale. Study investigators were contacted for missing details. We used both random- and fixed- effects models to estimate relative risks ( RRs). Results Twenty- nine randomized controlled trials totaling 8432 patients contributed data for this meta- analysis. Hospital mortality did not differ between tight glucose control and usual care overall ( 21.6% vs 23.3%; RR, 0.93; 95% confidence interval [ CI], 0.85- 1.03). There was also no significant difference in mortality when stratified by glucose goal ([ 1] very tight: <= 110 mg/ dL; 23% vs 25.2%; RR, 0.90; 95% CI, 0.77- 1.04; or [ 2] moderately tight: < 150 mg/ dL; 17.3% vs 18.0%; RR, 0.99; 95% CI, 0.83- 1.18) or intensive care unit setting ([ 1] surgical: 8.8% vs 10.8%; RR, 0.88; 95% CI, 0.63- 1.22; [ 2] medical: 26.9% vs 29.7%; RR, 0.92; 95% CI, 0.82- 1.04; or [ 3] medical- surgical: 26.1% vs 27.0%; RR, 0.95; 95% CI, 0.80- 1.13). Tight glucose control was not associated with significantly decreased risk for new need for dialysis ( 11.2% vs 12.1%; RR, 0.96; 95% CI, 0.76- 1.20), but was associated with significantly decreased risk of septicemia ( 10.9% vs 13.4%; RR, 0.76; 95% CI, 0.59- 0.97), and significantly increased risk of hypoglycemia ( glucose <= 40 mg/ dL; 13.7% vs 2.5%; RR, 5.13; 95% CI, 4.09- 6.43). Conclusion In critically ill adult patients, tight glucose control is not associated with significantly reduced hospital mortality but is associated with an increased risk of hypoglycemia.
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页码:933 / 944
页数:12
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