Restriction of foamy viruses by APOBEC cytidine deaminases

被引:112
作者
Delebecque, F
Suspène, R
Calattini, S
Casartelli, N
Saïb, A
Froment, A
Wain-Hobson, S
Gessain, A
Vartanian, JP
Schwartz, O
机构
[1] Inst Pasteur, CNRS, URA 1930, Virus & Immun Grp, F-75724 Paris 15, France
[2] Inst Pasteur, CNRS, URA 1930, Mol Retrovirol Unit, F-75724 Paris 15, France
[3] Inst Pasteur, CNRS, URA 1930, Epidemiol & Physiopathol Oncogen Viruses Unit, F-75724 Paris 15, France
[4] Inst Univ Hematol, Hop St Louis, F-75475 Paris 10, France
[5] IRD, Ermes, Orleans, France
关键词
D O I
10.1128/JVI.80.2.605-614.2006
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Foamy viruses (FVs) are nonpathogenic retroviruses infecting many species of mammals, notably primates, cattle, and cats. We have examined whether members of the apolipoprotein B-editing catalytic polypeptide-like subunit (APOBEC) family of antiviral cytidine deaminases restrict replication of simian FV. We show that human APOBEC3G is a potent inhibitor of FV infectivity in cell culture experiments. This antiviral activity is associated with cytidine editing of the viral genome. Both molecular FV clones and primary uncloned viruses were susceptible to APOBEC3G, and viral infectivity was also inhibited by murine and simian APOBEC3G homologues, as well as by human APOBEC3F. Wild-type and bet-deleted viruses were similarly sensitive to this antiviral activity, suggesting that Bet does not significantly counteract APOBEC proteins. Moreover, we did not detect FV sequences that may have been targeted by APOBEC in naturally infected macaques, but we observed a few G-to-A substitutions in humans that have been accidentally contaminated by simian FV. In infected hosts, the persistence strategy employed by FV might be based on low levels of replication, as well as avoidance of cells expressing large amounts of active cytidine deaminases.
引用
收藏
页码:605 / 614
页数:10
相关论文
共 77 条
  • [1] Intrinsic immunity: a front-line defense against viral attack
    Bieniasz, PD
    [J]. NATURE IMMUNOLOGY, 2004, 5 (11) : 1109 - 1115
  • [2] APOBEC-mediated editing of viral RNA
    Bishop, KN
    Holmes, RK
    Sheehy, AM
    Malim, MH
    [J]. SCIENCE, 2004, 305 (5684) : 645 - 645
  • [3] Cytidine deamination of retroviral DNA by diverse APOBEC proteins
    Bishop, KN
    Holmes, RK
    Sheehy, AM
    Davidson, NO
    Cho, SJ
    Malim, MH
    [J]. CURRENT BIOLOGY, 2004, 14 (15) : 1392 - 1396
  • [4] Cells expressing the human foamy virus (HFV) accessory Bet protein are resistant to productive HFV superinfection
    Bock, M
    Heinkelein, M
    Lindemann, D
    Rethwilm, A
    [J]. VIROLOGY, 1998, 250 (01) : 194 - 204
  • [5] Boeke J. D., 1997, P343
  • [6] A single amino acid difference in the host APOBEC3G protein controls the primate species specificity of HIV type 1 virion infectivity factor
    Bogerd, HP
    Doehle, BP
    Wiegand, HL
    Cullen, BR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (11) : 3770 - 3774
  • [7] Natural simian foamy virus infection in wild-caught gorillas, mandrills and drills from Cameroon and Gabon
    Calattini, S
    Nerrienet, E
    Mauclère, P
    Georges-Courbot, MC
    Saïb, A
    Gessain, A
    [J]. JOURNAL OF GENERAL VIROLOGY, 2004, 85 : 3313 - 3317
  • [8] Persistent zoonotic infection of a human with simian foamy virus in the absence of an intact orf-2 accessory gene
    Callahan, ME
    Switzer, WM
    Matthews, AL
    Roberts, BD
    Heneine, W
    Folks, TM
    Sandstrom, PA
    [J]. JOURNAL OF VIROLOGY, 1999, 73 (11) : 9619 - 9624
  • [9] RETRACTED: Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells (Retracted Article. See vol 466, pg 276, 2010)
    Chiu, YL
    Soros, VB
    Kreisberg, JF
    Stopak, K
    Yonemoto, W
    Greene, WC
    [J]. NATURE, 2005, 435 (7038) : 108 - 114
  • [10] The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G
    Conticello, SG
    Harris, RS
    Neuberger, MS
    [J]. CURRENT BIOLOGY, 2003, 13 (22) : 2009 - 2013