Cytokines in host defense against Salmonella

被引：219

作者：

Eckmann, L ^{[1
]}

Kagnoff, MF ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Med, Lab Mucosal Immunol, La Jolla, CA 92093 USA

来源：

MICROBES AND INFECTION | 2001年 / 3卷 / 14-15期

关键词：

microbial pathogenesis; innate immunity; chemokines; macrophages; intestinal epithelial cells;

D O I：

10.1016/S1286-4579(01)01479-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytokines are key communication molecules between host cells in the defense against the enteric pathogen, Salmonella. Infection with Salmonella induces expression of multiple chemokines and proinflammatory cytokines in cultured intestinal epithelial cells and macrophages. In animal models, protective roles have been shown for IL-1alpha, TNFalpha, IFN-gamma, IL-12, IL-18 and IL-15, whereas IL-4 and IL-10 inhibit host defenses against Salmonella. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

页码：1191 / 1200

页数：10

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