Evaluation of the treatment of port-wine stains with the 595-nm long pulsed dye laser: A large prospective study in adult Japanese patients

Background: Treatments of port-wine stains with conventional Pulsed dye laser yield inconsistent results. Objective: We evaluated the efficacy and safety of the longer pulse duration 595-nm dye laser. Methods: Sixty-six adult Japanese patients were enrolled in this prospective Study. The laser treatment with a cooling device was repeated 4 times at 8-week intervals with a consistent setting of 10-ms pulse duration and an energy fluence of 12 J/cm(2) using 7-mm spot size. Results: Improvement of port-wine stains was observed after multiple treatments, and 67% of the patients achieved either good or excellent response after the following treatment. Transient purpura, edema, or both were noted immediately after each treatment (76%-79% and 58%-67%, respectively). Hyperpigmentation (8%-17%) and hypopigmentation (6%-14%) were also mild and their occurrence did not increase by repeating treatments. Limitations: Eighty five percent of the patients were classified as having Fitzpatrick skin type IV. Conclusion: Our study indicated that the 595-nm dye laser with 10-ms pulse duration may be effective and well tolerated in the treatment of port-wine stains in adult Asians.